Medicine for psoriasis treatment to prevent diabetes

by time news

A research team from the University of Helsinki in Finland has found that a drug that treats psoriasis can be used to prevent type 1 diabetes. According to the study published in the latest issue of the journal Nature Communications, researchers demonstrated the effectiveness of the drug called “Deucravacitinib”, which was approved by the US Food and Drug Administration, in inhibiting the gene associated with the emergence of the disease.

The researchers hypothesized that inhibiting the expression of the gene (TYK2) could reduce the destruction of the “pancreatic beta cells” that cause the onset of type 1 diabetes, as these cells produce the body’s vital insulin, with which diabetics must replace insulin injections. The hypothesis was confirmed in the study, effectively stopping the destruction of “beta cells” by inhibiting the expression of the gene (TYK2).

“Destruction of[beta cells]is the result of an autoimmune reaction, in which white blood cells activated by the body’s immune system attack their own tissues, and using an inhibitor of the TYK2 gene,” says Timo Otunkowski, a professor at the University of Helsinki and the study’s lead author, in a report published on the university’s website. It is the approved medication for psoriasis, and the destruction caused by white blood cells has been significantly reduced.” In light of these results, which were performed on human cells in vitro, the gene inhibitor (TYK2) is a promising candidate drug for the prevention of type 1 diabetes, and the next step is to study its effect carefully in animal models, and if the results are positive, the next step can be taken for experiments Clinical.

The proposed mechanism for using this drug is as a preventative drug for people at high risk of developing the disease.

Otunkowski adds: “While hundreds of disease-causing genes have been identified, the mechanisms of action of most of them were still unclear. In other words, we could have identified individuals at high risk of developing the disease, but no effective way was found to prevent the development of the disease without the risk of effects. The big negative, and the proposed drug could be a suitable solution.”


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