Mouse Assisted Reproductive Technology | MART

Boston University Core Facility Advances Mouse Reproductive Technology,Safeguarding Research Integrity

A specialized core facility at Boston University is offering advanced reproductive technologies for mice,alongside crucial services to maintain the health and genetic integrity of research colonies.The Mouse assisted Reproductive Technology (MART) Core is equipped to support a wide range of research endeavors, from basic science to translational studies.

the MART core provides comprehensive support for researchers utilizing mouse models. Services include sperm collection, egg harvesting, in-vitro fertilization, and embryo transplantation. These capabilities are essential for studies requiring precise genetic manipulation or overcoming reproductive challenges in specific mouse strains.

Did you know? – In-vitro fertilization in mice differs from human IVF, often utilizing microinjection directly into the egg rather than relying on spontaneous fertilization.

Addressing Pathogen Risk in Mouse Colonies

A key focus of the MART Core is mitigating the risk of introducing pathogens into valuable mouse colonies. Researchers often acquire mice from external facilities or countries, possibly exposing their existing colonies to unknown health threats. To address this, the Core performs procedures like cesarean section, embryo transfer, and in-vitro fertilization to ensure offspring are born free of common mouse pathogens.

“Eliminating common mouse pathogens in offspring is critical for maintaining the validity of research findings,” a senior official stated.”The MART Core provides a vital service for researchers working with mice of uncertain health status.”

Pro tip – cesarean sections performed by the MART Core can help preserve the genetic background of valuable mouse strains that may have difficulty delivering naturally.

Beyond Core Technologies: Training and Collaboration

The MART Core extends beyond simply performing reproductive procedures. The facility also offers technical training and opportunities for collaboration on projects within their area of expertise. This commitment to knowledge sharing and partnership aims to accelerate scientific finding. All procedures are conducted within ABSL-2 laboratories, ensuring the preservation of the specific pathogen-free health status of the university’s mouse colonies and breeding programs.

Reader question – Can the MART Core assist with cryopreservation of mouse gametes or embryos? Yes, the facility offers cryopreservation services to safeguard genetic resources.

Significant Considerations for Researchers

Researchers should be aware that the success of these reproductive technologies can vary depending on the genetic strain viability of the mice being used. This underscores the importance of careful strain selection and experimental design.

For more information on available services or to request a price quote, investigators can contact John Mkandawire at [email protected]. Colleen Thurman, Director of the Animal Science Center, is also available for inquiries at [email protected].

Contact Information:

• John Mkandawire – Core Services Specialist
  • Cell: [phone]
  • Office: [phone]
  • FAX: [phone]
  • Email: [email protected]
• Colleen Thurman – Director, Animal Science Center
  • Office: [phone]
  • email: [email protected]

Location:

BU medical Center
700 Albany St., W707
Boston, MA 02118