The World Health Organization (WHO) has announced that it is monitoring two new subspecies of omikron, “BA.4” and “BA.5,” from the original four “BA.1, BA.1.1, BA.” .2, and BA.3″
On April 12th, the Medical Genome Center has posted a message via Facebook Center for Medical Genomics stated that
The World Health Organization has announced increased caution for two more omikron subspecies “BA.4” and “BA.5” out of four “BA.1, BA.1.1, BA.2, and BA.” 3″
According to a search from the Global COVID Genetic Code Database “GISAID” (4/12/2565), BA.4 and BA.5 have not been found in Thailand.
Update 4/13/2022 at 8:25
The World Health Organization (WHO) said on Monday it was monitoring two new subspecies of omikron cases, “BA.4” and “BA.5.” about 30-40 people to assess that
1. Will the BA.4 and BA.5 strains spread faster than BA.2? Because of the genome-wide analysis of the genetic code, BA.5 differs from the original Wuhan virus by almost “100 locations”. BA.4 was found to differ from the original Wuhan virus by “90 locations” (Figure 1).
A study of the mutation nature of the 2019 coronavirus found that the mutation location on the increased genome was directly proportional to the speed of the epidemic. For this reason, the WHO has urged all countries around the world to keep a close eye on these two species (Figure 2).
2. strains BA.4 and BA.5 will cause symptoms of COVID-19. more severe than omicron Are the subspecies “BA.1” and “BA.2” currently epidemic?
From the examination of the whole genome code of the coronavirus 2019 from the Global COVID-19 Database “GISAID”, “10,220,862 samples” from around the world were found.
-Strain BA.4 approximately “83 specimens” and
– Species BA.5, only “37 samples”, which does not reach the hundreds digits, making the speculation that Both virus strains may have evolutionary trajectories that are currently incompatible with the environment.
From a search of the World COVID Genetic Code Database “GISAID” on 4/12/22, BA.4 and BA.5 have not been found in Thailand (Picture 3).
It concluded that WHO is currently monitoring six subspecies of omikron, namely BA.1, BA.1.1, BA.2, BA.3, BA.4 and BA.5), and approximately an additional approx. Eight species are XD,XF, XE, XG,XH,XL,XK, and XJ (Picture 2).
The BA.4 and BA.5 strains share a very similar genetic code to the ‘BA.2’ omikron, with approximately two different mutations from the BA.2 omikron on the spiny segment, L452R, which is delta-like. and the Lambda and F486V, which are rarely seen in other variants.
The study of mutations that alter the spines was urgently needed to understand the immune evasion effects of these two new virus strains.
Incidentally, coronavirus 2019 has mutations all the time but only “Only certain mutations” can affect a virus’s ability to spread or evade immunity previously acquired through vaccination or natural infection. including affecting the increase or decrease in the severity of COVID-19
For example, the case of BA.2, which is 94 percent of the time globally, is more contagious than all previously infected strains of the 2019 coronavirus (except BA.4 and BA.5), but the evidence so far. This suggests that BA.2 is unlikely to cause severe disease as in the past delta beta alpha.
The UK’s Health Security Agency, which deciphers the whole genome of COVID-19 from global samples (whole genome sequencing), said last week that BA.4 was found in South Africa, Denmark. Botswana, Scotland and England from 10 Jan. to 30 Mar.
The BA.5 strain last week is still found only in South Africa. But on Monday, Botswana’s Ministry of Health reported that four BA.4 and BA.5 cases, aged 30-50, have been fully vaccinated. with mild symptoms
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