New Genetic Research Reveals Depression May Be a Direct Cause of Type 2 Diabetes
By Marc Lallanilla
Published Sep. 7, 2023, 9:56 a.m. ET
New genetic research has found a direct link between depression and Type 2 diabetes, according to scientists from the UK. It has long been known that patients with Type 2 diabetes are more likely to be diagnosed with depression, but it was unclear whether the diabetes caused the depression or vice versa. The new study has discovered seven genetic variants that contribute to both conditions, shedding light on the underlying mechanisms.
The identified genes play a role in insulin production and inflammation in the brain, pancreas, and fatty tissue. Changes caused by these genes can partly explain the processes involved in depression and how it increases the risk of developing Type 2 diabetes. Dr. Elizabeth Robertson, director of research at Diabetes UK, emphasized the importance of the study and stated that depression should now be considered a risk factor for Type 2 diabetes.
The research team analyzed genetic data from hundreds of thousands of UK and Finland residents, including individuals with Type 2 diabetes, diagnosed depression, and self-reported depression. Their analysis revealed that only 36.5% of the effect of depression on Type 2 diabetes could be attributed to obesity. Despite not finding a direct cause of diabetes leading to depression, medical experts still believe that having Type 2 diabetes may be a risk factor for developing depression.
As depression, Type 2 diabetes, and obesity have now been strongly linked by research, the study’s authors recommend that healthcare providers screen patients with depression for Type 2 diabetes and related conditions. Professor Inga Prokopenko of the University of Surrey, who led the research effort, hopes that their findings will improve prevention efforts and encourage additional examinations to prevent the onset of Type 2 diabetes in people suffering from depression.
The discovery of the genetic connection between depression and Type 2 diabetes is a significant step forward in understanding these complex conditions. It highlights the importance of considering mental health in relation to physical health and calls for a holistic approach to healthcare. With further research, this breakthrough could lead to more targeted prevention and treatment strategies for both depression and Type 2 diabetes.