Keep an eye on ‘Omicron CH.1.1’, a worrying strain Avoid immunity from 3 doses of mRAN vaccine, causing severe inflammation
The Medical Genome Center, Ramathibodi Hospital posted a Facebook page. Center for Medical Genomics Indicated that many parties are watching Omicron “CH.1.1” that found a pandemic in New Zealand. have immune evasion mutations superior to BQ.1.1 and XBB.1.5
and some spiny proteins like delta species can cause the fusion of adjacent cells to form a large cell. (fusogenicity) attracts the body’s immune system to destroy, causing more severe inflammation.
CH.1.1 first emerged in Southeast Asia in November 2022, then spread to the UK and New Zealand with 25% and 40% share of outbreaks respectively (Figure 1-2).
Omicron CH.1.1 causing severe inflammation like deltas
At present, approximately 10% of samples from randomly decoded genetically from around the world and shared on the global COVID-19 database “GISAID” were found to be CH.1.1.
The US Centers for Disease Control and Prevention (US-CDC) has announced that Omicron CH.1.1 is present in 1.5% of the United States (Figure 3).
Hong Kong and Papua New Guinea About a quarter of people in the country are infected with CH.1.1, while about a fifth of those infected in Cambodia and Ireland are infected with CH.1.1.
Thailand has detected CH.1.1 in 168 cases by random genetic decoding and data sharing on the global COVID-19 database “GISAID”, with a 5% share of the domestic epidemic (Figure 4).
Why Omicron CH.1.1 to worry?
CH.1.1 has a spinal region mutation at the “L452R” amino acid position similar to the delta strain. (Omicrons don’t normally have mutations in this location.) This can cause severe infections. as well as delta species
Because laboratory tests found that The mutated spines can attach to the surface of infected cells in a variety of organs in addition to lung cells. Causes the fusion of cells that are close together to become a large cell. (Fusogenicity) attracts the body’s immune system to destroy and cause more severe inflammation (Figure 5).
CH.1.1 is not a “Deltacron” with partial exchange of genome lines between Delta and Omicron strains. But Omicron’s great-grandson, BA.2.75, is a prime example of convergent evolution, i.e., the Covid species evolved independently. But instead, there is a mutation in the same form. (between Delta and Omicron strains) due to immune pressure from vaccines and natural infection among the population.
Avoid the landscape from vaccination. mRNA 3 the needle completely
Dr. Cornelius Romer, bioinformatics from the University of Basel in Switzerland. There is an opinion that the Omicron hybrid XBB.1.5 is still the most infectious COVID strain. According to the latest information on January 19, 2023, however, you should watch out for CH.1.1 because it can spread quickly as well. The number doubles every two weeks or so.
In addition, Omicron XBB.1.5, BQ.1.1, CH.1.1, and CA.3.1 resisted or completely evaded immunity obtained from three injections of native mRNA (monovalent vaccine). Those who received three full doses of the original mRNA vaccine followed by a bivalent booster mRNA vaccine were immune to omicrons XBB.1.5, BQ.1.1, CH.1.1, and CA.3.1 some (Figure 6-7)
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