“Omicron is ceasing to vary.” Study of the Altamedica Institute

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Omicron is behaving ‘smart’

According to the observation ofAltamedica Research Institute Omicron is ceasing to vary. The data relating to the last 68 sequencing of the viral genome with the NGS method say so. Of these 55 (about 80%) have the original form and 13 (about 20%) have very limited micro-mutations (called sublineage) that do not modify the substance.

“We can say that the Omicron appears stable – says the professor Claudio Giorlandino, scientific director of the Altamedica Research Institute – Our study focused on the important changes of the last 15 days in which Omicron has grown rapidly to reach 100% positive cases today. We have focused our attention above all on the outpatients, that is, the thousands or hundreds of thousands of subjects who become infected but who remain at home, not presenting severe pathologies and which today represent 99.7% of the infected. Fromlla observation of 3,486 positives out of about 21,000 examined from 8 December to 22 January, it emerged that Omicron determines, in fact, a rhino-pharyngo-tracheitis. The few more severe cases (about 2%) are probably attributable to the tail of the Delta. “.

I study

“In fact, in 45 days, among the 3,486 reports of infected people sent to the ministerial platform we researched, on a sample basis, the genotype, observing a progressive reduction of Delta infections and, particularly in the last few weeks, truly reassuring data emerged that we can summarize as follows: in the meantime the percentage of positive swabs has decreased by 1 point, currently reaching 16.5%, a slight decrease compared to the average of the previous month (8 December / 7 January) which was 17.5% – he says Giorlandino – The most important observation lies in having documented that the percentage of the variants examined by sample weekly, has seen a progressive reduction of the more aggressive variant, the Delta, which, however, has not yet disappeared at all, settling around 15% up to to last week. Currently, this past week, out of 68 sequences, of the dangerous Delta, no trace has been found ”.

“The Micron is a variant of the Sars-Cov-2 virus which is transmitted very easily with the salivary droplets of the Flugge, being a virus that is mainly localized in the upper airways. Compared to the Delta variant, this does not engage in those cells that have a surface protein called transmembrane serine protease 2 (TMPRSS2). This protein, highly expressed by the respiratory endothelial cells of the lung, digestive system and prostate, is a co-receptor of the virus entry gate, the Ace2 receptor, and offers an excellent docking plane for the Delta spike but is not linked by that of Omicron. Therefore, this last variant in attacking the cells does not prefer, like the other 50 known variants, the organs most interested in morbidity, such as the lungs, where instead, as mentioned, TMPRSS2 is overexpressed. The literature is in fact stressing the concept that the difference in the way of entry between the Omicron and Delta variants can have an implication on the clinical manifestations or on the severity of the disease ”, adds the scientific director of Altamedica.

“This accounts for the fact that many ICUs have recently noticed two things, the first is the reduction in accesses for Covid, although the Omicron pandemic is rampant, and the second, especially where accurate sequences of the new variant have been performed, is the total absence of the same variant in ‘critical’ patients. The University of Berkeley, analyzing the California health databases, noted that in recent days, out of 50 thousand individuals affected by the South African, only 7 ended up in intensive care and only 1 died from different complications. But even here, in Bergamo, the intensive care recently reported the absence of Omicron ”, concludes Giorlandino.

According to the observation from the Altamedica Research Institute, Omicron is ceasing to vary. The data relating to the last 68 sequencing of the viral genome with the NGS method say so. Of these 55 (about 80%) have the original form and 13 (about 20%) have very limited micro-mutations (called sublineage) that do not modify the substance.

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