“Only cancer gene mutations are killed… Vitamin B3 can overcome the limitations of targeted therapy”[기고/배석철]

It is very difficult for cancer treatments to selectively kill only cancer cells, so inevitably normal cells are damaged in the process. Getty Images Korea

Bae Seok-cheol, Professor, Chungbuk National University College of Medicine

Why does modern medicine struggle to treat cancer, even though it is effective in treating other diseases?

The main reason is that it is extremely difficult to selectively remove cancer cells. Cancer cells are originally normal cells that have been transformed by mutations in one or two important genes, so their survival principles are similar to those of normal cells, making it very difficult to selectively remove only cancer cells.

These problems can lead to serious side effects after cancer treatment. Chemotherapy drugs damage not only cancer cells but also some normal cells, and in particular, there are many cases where dividing normal cells die together. Before the 2000s, substances that selectively kill dividing cells were considered excellent anticancer drugs, but they are not used much now due to the serious side effects they cause. Recently, targeted anticancer drugs developed according to strategies targeting specific genes are being widely used.

However, since these targeted anticancer drugs also have the same fundamental concept of targeting dividing cells as in the past, they are accompanied by serious side effects. This occurs because the genes on which targeted therapies act are often present not only in cancer cells but also in dividing normal cells.

As the culmination of modern life science, targeted anticancer drugs have made groundbreaking contributions to the field of cancer treatment, but their limitations are also being revealed. However, this is a limitation of modern cancer treatment strategies that focus on attacking oncogenes, not a limitation of humans. Human cells have an amazing cancer defense system. This system effectively detects subtle differences caused by mutations in oncogenes and prevents the development of cancer by causing the corresponding cells to commit suicide. This cancer defense system is incredibly sensitive, so it can accurately detect oncogene mutations occurring in one cell out of hundreds of trillions of cells and selectively kill only that cell. Numerical calculations prove that if this excellent cancer defense system did not exist, all humans would have cancer before birth.

So why do humans with such a powerful anti-cancer defense system get cancer? This is because when a cancer gene mutation occurs in a cell in a dormant state of the anti-cancer defense system, which is rarely created, the cell cannot commit suicide, causing cancer. Therefore, if the dormant anti-cancer defense system can be reactivated, this amazing system will be able to immediately detect the oncogene mutation in the cancer cell and completely eliminate it.

The existence of this system has been known in academia for a long time, but the specific operating principle and activation method have not been discovered until recently. My research team was the first to elucidate the operating principle of the cancer defense system, published a related paper in ‘Nature’ in 2019, and was also the first to discover a substance that can activate this system. Through a five-year clinical trial, we confirmed that this substance can contribute to cancer treatment beyond the limitations of targeted therapy. Surprisingly, this substance is ‘vitamin B3’. The results of a clinical trial that showed that when 1g of vitamin B3 was administered orally per day, the average life expectancy of cancer patients receiving targeted anticancer therapy significantly increased and the risk of death was significantly reduced were recently published in a specialized academic journal. Recently, the results of a clinical trial by an overseas group that cancer prevention is possible with 1g of vitamin B3 per day were also published. Therefore, the activator of the cancer defense system is not that it has not yet been released to the world, but that it has just been released and is not yet known to the world.

Since vitamin B3 can be safely taken for long periods of time in doses of up to 3g per day, these research results suggest that vitamin B3 is a “godsend” for cancer treatment and prevention. Although other vitamins are also claimed to help prevent and treat cancer, vitamin B3 is the only vitamin whose mechanism of action has been clearly identified and whose safety and efficacy have been proven through clinical trials.

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2024-09-11 08:31:01