Scientists have discovered how chemicals produced by Cordyceps militaris inhibit the growth of cancer cells. This is considered an important advancement in the development of new treatments using Cordyceps sinensis. In particular, it is expected to be an effective treatment because it can inhibit the growth of cancer cells while minimizing damage to healthy cells.
The compound in question, cordycepin, has long been evaluated as having beneficial health effects, but its specific mode of action was not clear. The study found that cordycepin works by blocking uncontrolled cell growth-promoting signals that are a hallmark of cancer.
It is expected to be an alternative treatment because it can reduce the negative effects on healthy cell tissue compared to most currently used anti-cancer treatments.
Researchers at the University of Nottingham in the UK published new research results on cordycepin, one of the chemicals secreted by Cordyceps sinensis, in the journal FEBS Letters on the 7th (local time).
Cordyceps sinensis, a fungus that lives on caterpillars, is famous as a health food and traditional medicine in Asian countries such as Korea, China, and Tibet. Cordycepin, produced by Cordyceps sinensis, has shown potential as an anticancer agent in various studies, but its mode of action is not fully understood.
The researchers used high-throughput techniques to measure the effect of cordycepin on the activity of thousands of genes in several cancer cell lines. As a result of comparing the effects of cordycepin with the effects of other treatments accumulated in the database, it was confirmed that it was effective in all cases. Additionally, it was confirmed that cordycepin is converted into cordycepin triphosphate, an analogue of ATP (adenosine triphosphate), the energy carrier of cells, within cancer cells. Cordycepin triphosphate is a major contributor to cell growth and has been identified as a molecule that can directly affect cancer cells.
Accordingly, the researchers confirmed that “cordycepin triphosphate is an active metabolite of cordycepin and that it consistently suppresses gene expression induced by growth factors.” Through various analysis methods, we confirmed that cordycepin blocks the growth factor signaling PI3K/
AKT/mTOR and MEK/ERK pathways in six cell lines, and that AMPK activation is not required.” “It acts in the form of cordycepin triphosphate, indicating that it has a universal mechanism of action that acts on as yet unknown target molecules involved in growth factor signaling,” they wrote.
“We have been studying the effectiveness of cordycepin for a variety of diseases for many years, and we need to understand how we can use cordycepin as an effective treatment at each stage,” said Dr. Cornelia de Moore, a professor at the School of Pharmacy who led the study. “Our data confirms that cordycepin could be a good starting point for new cancer treatments, and that derivatives of this drug can be targeted in the triphosphate form to achieve the same effect.” “I can.” Researchers have developed an effective anti-cancer treatment that minimizes side effects using compounds from Cordyceps sinensis.
I’m looking forward to doing it.
참고자료: Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology study.(-
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Researchers from the University of Nottingham have made significant strides in understanding how cordycepin, a compound derived from the fungus Cordyceps sinensis, can inhibit cancer cell growth. Their findings, published in FEBS Letters, show that cordycepin can block key signaling pathways that promote uncontrolled cell growth, a characteristic of cancer.
Cordycepin has been recognized for its potential health benefits, but the specifics of its action have remained elusive. This study demonstrated that cordycepin is converted into cordycepin triphosphate, which can directly influence cancer cells by mimicking adenosine triphosphate (ATP), the primary energy molecule in cells. The research confirmed that cordycepin triphosphate works to suppress gene expression driven by growth factors, which are critical in tumor development.
Importantly, the study highlights that cordycepin may offer a less harmful alternative compared to traditional anti-cancer treatments, as it appears to target cancer cells while sparing healthy cells. The team’s work suggests that modifications to cordycepin could lead to future cancer therapies with minimized side effects.
Dr. Cornelia de Moore, the lead researcher, emphasized the need for further investigation into the therapeutic usage of cordycepin at various disease stages, indicating its potential as a cornerstone for new cancer treatments.
These discoveries showcase the promise of natural compounds in the fight against cancer, paving the way for innovative therapies based on traditional medicine.