As a tennis player seeded with number 24, Ostapenko has a free first round, but Bjerklund (WTA 149) defeated the Italian Jazmina Paolini (WTA 71) in the first round with 4-6, 6-3, 6-3.
Ostapenko ranks 22nd in the WTA ranking and has not met the Swedish tennis players.
In the doubles match, Ostapenko with her usual opponent Ludmila Kichenok from Ukraine is seeded third in the tournament and will face American Danielle Collins and Peyton Stearns in the first round.
The tournament in Miami will take place on the hard surface until April 2.
Last year, the WTA ranking leader Polish Iga Šviontek became its winner, who defeated Japanese Naomi Osaka in the final.
Ostapenko lost the first match in singles and the second match in doubles last year in Miami.