2024-09-25 04:00:19
The anticancer drugs involved are in part tyrosine kinase inhibitors (TKI), targeted therapies used to treat lung cancer or sarcomas, for example, and on the other hand checkpoint inhibitors, used in immunotherapy.
Proton pump inhibitors (PPIs), such as omeprazole or lansoprazole, help reduce stomach acid. They are indicated for stomach or duodenal obstruction, esophagitis or gastroesophageal reflux. They are often used during treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), in order to limit their unwanted effects.
“The Exterminator”
PPIs, some of which are available without a prescription, are widely consumed in France. According to one The study was conducted in 2015around 30% of the population has taken during the year, and almost half of those over 65. “Many patients are treated chronically, often outside the marketing authorization indications, and sometimes for several years”notes Dominique Deplanque, professor of pharmacology at Lille University Hospital.
In February 2024, French researchers published in the magazine Cancer Treatment and Research Communications the study also concluded that “The Exterminator” between IPP and ITK. They are based on Medicare reimbursement data between 2011 and 2021. In more than thirty-four patients treated with TKI for so-called “non-small cell” lung cancer, they observed death the risk increases if the patient drinks, comparatively. , a PPI accounts for less than 20% of their cancer treatment duration. “And the longer the patient was exposed to the PPI-TKI interaction during their TKI cancer treatment, the higher the risk of death.”specified Constance Bordet, doctor of pharmacy at the University of Toulouse, and the first author of the study. The TKIs studied were erlotinib, gefitinib, afatinib, and osimertinib.
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