Research Reveals Challenges in Developing RSV Vaccines: Doctor Yong Discusses Re-Infection and Annual Incidences

by time news

2023-09-25 03:15:00
Monday, September 25, 2023, 8:15 a.m.

Solve the answer! ‘Doctor Yong’ reveals research results. ‘RSV’ children can become infected again. Some people get it every year. There are many problems in developing ‘vaccines’.

25 September 2023 – In a groundbreaking announcement, Professor Dr. Yong Phuworawan, the Head of the Center of Specialization in Clinical Virology at the Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, has revealed that children affected by respiratory syncytial virus (RSV) can become infected with the virus again. Dr. Yong made this revelation via a Facebook post, highlighting the recurring nature of RSV in some children.

RSV, a disease that has been known to reoccur, particularly in children, leads to severe symptoms such as bronchitis and bronchiolitis. Dr. Yong explained that the first instance of RSV infection often comes with the most symptoms. Typically, more than 80% of individuals inherit immunity from their mothers, which fades away around 6 months after birth. Consequently, children are more vulnerable to contracting RSV after the 6-month mark. The respiratory infection, commonly requiring hospitalization, can even lead to the administration of oxygen in severe cases.

While treatment for RSV is generally palliative, as patients are advised to wait for symptoms to subside, fatalities from RSV in Thailand are rare, except in impoverished countries where malnutrition is prevalent.

One concerning finding from the research conducted by Dr. Yong’s team at the Center is that subsequent infections can occur even after a person has overcome a previous bout of RSV. In their study of 81 re-infected individuals, it was revealed that 72 experienced a recurrence once, while 9 were re-infected twice, resulting in a total of 3 infections. Most of these reinfections occurred in children below the age of 5. Surprisingly, some children, upon reaching the age of 5, continued to be infected annually, albeit without an official diagnosis.

Further investigations into the strain of RSV were conducted on these 81 infected children. Two main strains of RSV, A and B, along with various subtypes, were identified during the genetic analysis. The study determined that individuals who were infected with RSV strain A in a particular year could be susceptible to reinfection the following year, either from strain A or strain B. Unfortunately, the primary strain did not offer cross-protection or protection against the same species. Even sub-strains like the ON1 strain could lead to reinfection the following year.

The development of a vaccine for RSV has proven to be a challenge, especially when it comes to children. Although vaccines have been introduced for use in the elderly and pregnant women, ensuring long-term protection remains elusive.

Dr. Yong’s research sheds light on the complexities of RSV and serves as a call to action for the medical community to delve deeper into finding effective preventive measures against this recurrent and potentially dangerous disease.]
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