2024-08-22 07:00:38
Researchers have shed light on development of acute myeloid leukemia (AML). International research published in ‘Nature Blood’ offers a new perspective to better understand change bad of the cells involved in the disease. And the genetic complexity of acute myeloid leukemia makes it difficult to treat. treatment.
Among the discoveries of scientists, many proteins are found in the formation of cellular substances. The work is led by Bruno Di Stefano from the Center for Stem Cells and Regenerative Medicine (STAR) and the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine in the US had a five-year survival rate of 30%
Acute myeloid leukemia is a Very aggressive blood cancer and accounts for approximately 25% of childhood leukemia, which usually develops during infancy. However, the incidence of acute myeloid leukemia increases with age; It is the most common acute leukemia in the elderly, with a median age of onset of 68 years. Located in the bone marrow, the transformed hematopoietic progenitor cells fail to differentiate properly and continue to proliferate uncontrollably.
Researchers note that AML cells have a higher number of P-body (cellular structures related to RNA processing). It means a key step in gene expression.
They discovered that ARN of tumor suppressor genes (those that prevent the oncogenic transformation of the cell) accumulate there and are not translated, so they cannot carry their proteins and, therefore, guide the fate of the cell.
It can be successful in fighting the disease
When the scientists forced the P antibodies to dissolve, the cells restarted their anti-cancer systems, reprogrammed their genes, restarted healthy gene expression patterns, and adopted a much more tolerant behavior, perhaps dying. or die. moving towards a non-proliferative state.
José L. Sardina, researcher at the Josep Carreras Institute and co-author of the work, believes that these results are an important step in the study of acute myeloid leukemia: “AML is a different disease; therefore, the discovery of the molecular method can be the Achilles heel for many different types and the changes in leukemia are very interesting.”
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