2023-06-06 08:43:45
In the study, a group of mice was given a saline solution with 2 percent sodium chloride for 12 weeks and their blood pressure was closely monitored.
A number of critical changes occurred in the brains of the mice.
The number of phosphates that provide the ‘Alzheimer’s protein’ tau increased. In contrast, the enzyme CaMKII, which is involved in the signaling function of the brain, decreased.
The researchers then looked at changes in the hormone angiotensin II (Ang II) and its receptor AT1 and the lipid molecule prostaglandin E2 (PGE2) and its receptor EP1. Ang II plays a crucial role in fluid balance and blood pressure regulation, and PGE2 is associated with high blood pressure and nervous system effects.
The results showed that a lot of salt influences these factors. High blood pressure caused by salt causes cognitive dysfunction in the interaction between Ang II-AT1 and PGE2-EP1.
Japan’s population is aging very quickly, and dementia is very common in the country.
And because there are currently no treatments that can cure the disease, the new study is a good step forward in research into cognitive impairment.
“This study is of great social and economic importance because the annual social costs of dementia treatment in Japan are rising like never before,” said Akihiro Mouri, co-author and professor at Fujita Health University.
The people of Japan are also very attached to salt, as salt is considered sacred and is a natural part of most meals.
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