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Washington, 2025-06-17
Surgery Wins Over GLP-1 Meds for Weight Loss
Bariatric surgery shows significantly better weight loss results compared to popular GLP-1 medications.
- Bariatric surgery led to roughly five times more weight loss than GLP-1 medications.
- Study included 38,545 patients on injectable Semaglutid or Tirzepatid and 12,540 who had bariatric surgery.
- A new blood test may help reduce liver transplant failures.
Wondering which is more effective for shedding those extra pounds? According to a recent study presented at the American Society for Metabolic and Bariatric Surgery conference, bariatric surgery proved to be much more effective than the increasingly common GLP-1 medications, with patients experiencing significantly greater weight loss.
Researchers compared data from a real-world study, revealing that those who underwent bariatric operations lost about five times more weight than those using weekly injections of GLP-1 medications. Dr. Avery Brown from Nyu Langone Health, the study director, noted that while clinical studies show a 15 to 21 percent weight loss for GLP-1 medications, real-world results are often lower, even with consistent use over a year.
The study examined records of 38,545 patients who were prescribed injectable Semaglutid or Tirzepatid between 2018 and 2024, and 12,540 patients who had bariatric surgery in the same period. All participants began with a body mass index of at least 35, indicating severe obesity. Semaglutid is the main ingredient in Wegovy and ozempic, while Tirzepatid is the primary component of Zepbound and Mounjaro.
After three years, patients who had sleeve gastrectomies or stomach bypasses lost an average of 24 percent of their initial weight. In comparison, those on medication lost around 5 percent after at least six months, and about 7 percent after a year.
Dr. Brown pointed out that up to 70 percent of GLP-1 patients might stop treatment within a year. Dr. Ann M. Rogers, ASMBS President, who was not involved in the study, emphasized the effectiveness and permanence of metabolic and bariatric surgery. She suggested that those who haven’t seen sufficient results with GLP-1 medications or are struggling with side effects or costs should consider bariatric surgery.
New Blood Test Revolutionizes Liver Transplant Monitoring
An innovative blood test could help detect issues in newly transplanted livers early on.
An experimental blood test could help surgeons identify problems in newly transplanted livers at an early stage, according to new research. Complications, which may arise during the transplant process, frequently enough show up later in standard blood tests. However, pinpointing the exact location of the damage typically requires costly imaging and surgical biopsies.
The new test works by tracking DNA fragments released by dying cells in the blood. Researchers can precisely determine the original cell type and the damage location based on the chemical signatures on these DNA fragments.
Dr. Alexander Kroemer from Medstar Georgetown University Hospital in Washington,DC,explained that identifying the specific part of the liver affected,such as bile ducts or blood vessels,”could offer a more personalized treatment approach that leads to better care for the patient.” The blood test is faster, less invasive than a traditional biopsy, and possibly more precise as biopsies sample only a small portion of the liver, and problems can be overlooked.
Georgetown has applied for a patent for the technology, and the research team is actively seeking partners to commercialize the test.
Muscle Ultrasound May Predict Diabetes Risk
Ultrasound of thigh or shoulder muscles may recognize early signs of insulin resistance.
Researchers have discovered that ultrasound examinations of thigh or shoulder muscles can identify insulin resistance in its earliest stages. Study director Dr. steve Soliman from the University of Michigan noted that his team has observed unusually shining muscles in many patients during shoulder ultrasound examinations.
Previous studies showed that most of these patients had type 2 diabetes.Though, some also displayed light muscles on ultrasound images without signs of diabetes or prediabetes. During short-term follow-ups, these patients often developed prediabetes or type 2 diabetes.
The team performed muscle ultrasounds on 25 patients, who were also tested for insulin resistance, to assess the potential of non-invasive muscle ultrasound as an early predictor of pre- or type 2 diabetes. Although the muscle ultrasound demonstrated insulin resistance and impaired insulin sensitivity, there was no direct link between the degree of brightness and the extent of the disease in this small study. Researchers are now recruiting additional participants to continue their analysis.
The researchers said that the exact reason why muscle brightness on the ultrasound image could indicate insulin resistance is less clear than finding that it does. Soliman said that “clinics increasingly use these point-of-care and hand ultrasound devices, which are sometiems referred to as the ‘stethoscope of the future’, for the fast diagnosis of various diseases.”
He added that a medical assistant or a doctor with limited training could easily use the device on a patient’s upper arm or thigh to routinely check weight or blood pressure, and possibly mark a patient as “high risk” or “low risk” for further testing.
Beyond Weight Loss: Exploring the Broader Picture of Bariatric Surgery
While the recent study highlighted the superior weight loss outcomes of bariatric surgery compared to GLP-1 medications, it’s crucial to explore the broader implications and patient experience beyond just the numbers. After all, successful weight management involves more than just shedding pounds; it’s about improving overall health and quality of life. Given the significant weight loss achieved through bariatric procedures, it is essential those considering surgery understand the profound impact these procedures may have.
Bariatric surgery, encompassing procedures like gastric bypass and sleeve gastrectomy, fundamentally alters how your body processes food. These surgeries are more than just a swift fix.They represent potentially life-changing options for individuals struggling with severe obesity and related health conditions.Thinking about bariatric surgery? You’ll be addressing not only weight, but frequently enough the complications that come with it. These procedures lead to metabolic shifts, which can positively influence a range of health issues.
Did you know? Bariatric surgery can lead to remission or improvement of conditions like type 2 diabetes, hypertension, and sleep apnea. The positive effects often go beyond the scale, improving the patient’s overall vitality.
One of the most significant benefits of bariatric surgery frequently enough includes the effect on type 2 diabetes. Many patients experience remission of the disease, even before significant weight loss occurs, suggesting a direct impact on metabolic function.This is achieved through a combination of reduced calorie intake and changes in gut hormones that regulate blood sugar levels.
Moreover, bariatric surgery can alleviate or resolve other obesity-related health problems. These include high blood pressure (hypertension), sleep apnea (chronic breathing pauses during sleep), and fatty liver disease. The reduction in these conditions not only improves physical health but also reduces the risk of cardiovascular disease, stroke, and other serious health complications. Wondering if bariatric surgery is right for you? consider more than just the number on the scale. Weigh the potential benefits against the risks!
Practical Tips to Maximize the Benefits of Bariatric Surgery
To ensure the best possible results from bariatric surgery, patients must actively participate in their care beyond the operating room. Lifestyle changes are critical to long-term success. Here’s a guide to help navigate the changes ahead:
- Follow Dietary Guidelines: Adhere strictly to the post-operative diet, which progresses from liquids to soft foods and then to solid foods. Prioritize protein intake and limit processed foods.
- embrace Regular Exercise: Incorporate regular physical activity into your daily routine. Aim for at least 150 minutes of moderate-intensity exercise per week.
- Stay Hydrated Drink plenty of water throughout the day to maintain hydration and support metabolic function.
- Attend Support Groups: Engage with support groups or online communities. Sharing experiences with other patients can provide invaluable emotional support and practical advice.
- Prioritize Mental Health: Seek counseling or therapy to address any emotional issues related to eating, body image, or lifestyle changes.
Bariatric surgery is a robust tool; achieving long-term positive results depends on consistent lifestyle changes. Patients who actively embrace these changes are more likely to maintain weight loss and improve their overall health and well-being.
FAQs About Bariatric Surgery
Q: What are the potential risks and complications of bariatric surgery?
A: Like any surgery, bariatric procedures carry risks, including bleeding, infection, blood clots, and, in rare cases, leaks from the surgical site. Long-term complications can include nutritional deficiencies and dumping syndrome.
Q: How long does it take to recover from bariatric surgery?
A: Recovery time varies,but most patients can return to light activities within a few weeks. Overall recovery usually takes a few months to ensure the body is adapting to the changes.
Q: Will I need to take supplements after bariatric surgery?
A: Yes, most patients require lifelong vitamin and mineral supplementation to prevent deficiencies. Your doctor will recommend specific supplements tailored to your procedure and individual needs.
Q: how does bariatric surgery affect the consumption of alcohol?
A: Alcohol absorption is often faster after bariatric surgery, leading to a quicker and potentially stronger effect. This can increase the risk of alcohol abuse. Patients must exercise caution and follow their surgeon’s recommendations regarding alcohol consumption.
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