2024-04-05 07:21:45
- Although allergic reactions are possible, There is no known toxicity associated with high doses (dietary or through the intake of dietary supplements) of the phylloquinone (vitamin K1) or menaquinone (vitamin K2) forms of vitamin K.
- The same does not happen with the vitamin K3 or synthetic menadionewhich can interfere with the function of glutathione, the body’s main natural antioxidants, causing oxidative damage to cell membranes.
- Menadione administered by injection has induced liver toxicity, jaundice, and hemolytic anemia (due to the breakdown of red blood cells) in infants; therefore, Menadione is no longer used for the treatment of vitamin K deficiency.
- It is therefore that No tolerable upper intake level (UL) has been established for vitamin K..
Vitamin K is an essential fat-soluble vitamin that plays a vital role in production of coagulation proteins. It also plays an important role in bone health.
How do I know if I have a high level of vitamin K?
It has been shown that despite ingest high amounts of vitamin K – K1 or phylloquinone, which is vitamin K obtained through diet – is not toxic.
Vitamin K2 also shows no adverse effects when ingested orally.. Studies have shown that coagulation research in humans did not show an increased risk of blood clots. when 45 mg per day of vitamin K2 were ingested (like MK-4). The researchers observed this in one patient who took more than 135 mg per day (45 mg three times a day).
As described, it is very unusual to obtain vitamin K toxicity, however, normal ranges in blood would be determined by:
Serum LevelsValues (ng/ml)Range 0.2-1
Diseases related to excess Vitamin K
The only toxicity reported is from menadione, which has no use in humans. It is believed that its toxicity is associated with its water-soluble properties. When toxicity occurs, it manifests itself with signs of jaundice, hyperbilirubinemia, hemolytic anemia and kernicterus in infants.
How to regulate your Vitamin K levels?
To regulate vitamin K levels, as we have described there is no upper limit of toxic level, it will be when there is a nutritional deficiency and it has been determined by a blood test. The medical professional will be able to prescribe the appropriate treatment for such a case.
Bibliography
Symptoms of excess of other vitamins:
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