The Gut-First Hypothesis: Exploring the Link Between Parkinson’s Disease and the Digestive System

New evidence suggests that Parkinson’s disease may originate in the gut before spreading to the brain, according to recent research. The “gut-first” hypothesis proposes that abnormal proteins in the gastrointestinal tract lead to the formation of toxic clumps that disrupt nerve cell function. This theory is supported by the fact that constipation, a common symptom of Parkinson’s, is considered a risk factor for the disease. Additionally, a meta-analysis found that patients with inflammatory bowel disease have a greater likelihood of developing Parkinson’s. The link between the gut and Parkinson’s has prompted researchers to investigate early prevention and treatment options. However, more research is needed to fully understand the causes of Parkinson’s and develop effective therapies.