2024-07-08 23:36:00
MEXICO CITY (apro).- Scientists from Finland and Sweden conducted a study to determine the effect of intense exercise on the mobilization of anti-tumor and pro-tumor immune cells in women with breast cancer.
Researchers from the University of Turku in Finland and the Karolinska Institute in Sweden, which awards the Nobel Prizes in physiology and medicine, conducted the study published at the end of June in the scientific journal Frontiers in immunology.
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The scientists selected 19 newly diagnosed breast cancer patients, aged between 36 and 68, to perform 30 minutes of moderate-intensity exercise with a bicycle ergometer.
Blood samples were collected at different times: at rest, at 15 and 30 minutes after the start of exercise, and at 30 and 60 minutes after exercise. The scientists then analyzed different subsets of immune cells using flow cytometry, which is the method of determining the number of cells, the percentage of living cells, and certain characteristics of the cells, such as size and shape.
The results showed that acute exercise increased the total number of immune cells, called leukocytes or white blood cells, such as: neutrophils, lymphocytes, monocytes and neutrophils, among others, such as cytotoxic T cells, called “killer cells natural.”
But some of the changes were temporary; for example, the proportions of some cells, such as “natural killers”, increased, while others, such as myeloid-derived suppressors (MDSCs), which are thought to play a causal role in cell proliferation, increased. reduced tumor-related immunity. The proportion of regulatory T cells – which prevent the immune system from overpowering – did not change with exercise.
Traditionally, doctors have advised patients to rest during cancer treatments, this has changed due to the positive effect of exercise on the disease and side effects associated with treatment, as well as associations with a more positive prognosis .
According to specialists, exercise seems to be the only effective way to reduce treatment-related fatigue. Cancer patients are now advised to exercise.
According to studies on sedentary behavior and cancer prevention and control, the likelihood of being diagnosed with breast cancer is 13% lower among people who are more physically active than among the least active. Cancer-specific mortality is 31% lower in physically active people, after diagnosis, compared to sedentary patients.
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