2023-06-16 02:30:21
16 June 2023 – Prof. Dr. Teerawat Hemajutha, Head of Emerging Disease Health Sciences Center Faculty of Medicine Chulalongkorn Hospital Post a message on Facebook that frequently use laxatives, laxatives, dementia risk
The use of single or combination laxatives increases the risk of dementia… This report was published February 22, 2023 in Neurology, the official journal of the American Neurological Society.
The analysis was based on data collected from a population of more than 500,000 middle-aged and older people gathered in the UK’s Biobank from a working group in China.
People who regularly use a type of laxative called osmotic laxatives have an increased risk of dementia. Compared to 64% of non-users and those using one or more types of laxatives. Both bulk-forming, stool softening and stimulant laxatives had a 90% higher risk.
There are different types of laxatives, including laxatives that draw water into the intestines and soften loose stools. And easier to pass (oxidative laxatives), such as lactulose polyethylene glycol sorbitol magnesium citrate sodium acid phosphate
bulk-forming laxatives such as mucillin metamucil
Stool softening (emollient) laxatives, such as colace docusate sodium arachis oil, help water and fluid mix with the stool.
Stimulant laxatives such as bisacodyl, dulcolax senna, and senokot sodium picosulfate stimulate the nerves that control the muscles to increase intestinal peristalsis.
Characteristics of different levels of constipation It is a phenomenon that is found frequently and is growing more and more. when getting older It is also possible to use different types of laxatives to alter the microflora or bacteria in the gut. through a mechanism that is transmitted from the nerves of the intestine up to the brain And from adding to the production of toxins (toxins) that cause inflammation, leakage of the intestinal wall and spread throughout the body and affect the functioning of the brain.
The population included in the reported cohort was 502,229, of which 54% were women, and all had a mean age of 57 at study start. All of them had no symptoms of dementia in the beginning.
Of the 18,335 people included in the study, 3.6% were using over-the-counter (OTC) laxatives, using them regularly for several days of the week. during the month prior to the start of the study
The average total follow-up was 9.8 years, with 218 cases, or 1.3%, who used laxatives consistently developed dementia. While 1,969 comparisons or 0.4% who did not use laxatives had dementia.
When adjusting values or factors including age, gender, education level illness and other medications used, including a family history of dementia or not
It was found that regular use of laxatives Significantly increased risk of all-cause dementia (adjusted hazard ratio) [aHR]1.51; 95% CI 1.30-1.75) and risk of generalized capillary dementia or vascular dementia (aHR, 1.65; 95% CI, 1.21-2.27). Alzheimer’s dementia ( aHR, 1.05; 95% CI, 0.79-1.40).
Dementia risk also depends on the type or type of laxative.
For those who use oxidative laxatives alone, there is a risk of all types of dementia. with statistical significance (aHR, 1.64; 95% CI, 1.20-2.24) and risk of vascular dementia (aHR, 1.97; 95% CI 1.04-3.75).
However, it was not possible to determine the dose of laxatives used in the population included in this study. How will it affect dementia?
Such information is shocking. and supporting the link between gut health and microbiota. and good and bad bacteria that direct the immune system to the nerves and to the brain.
but at the same time It is not yet possible to conclude or rationally prove the use of laxatives in the occurrence of the aforementioned types of dementia. But further in-depth study is required. both at the animal and human levels.
It is worth noting that different types and types of this laxative are used. Instead, they did not find an increased risk of Alzheimer’s dementia, which may be a limitation of the data or a limitation of dementia type identification, or may be in fact unrelated.
In summary about constipation or “hard elements” that the ancient people said by reiterating to his children that If not taken, there will be toxic accumulation spreading all over the body, probably true.
And the easiest way is to eat a lot of vegetables, fruits, fiber on a regular basis, several meals a day. The fibrous fruits and vegetables act as wonderful laxatives. But there is a condition that you must drink a lot of water to be effective. And, of course, it has to be as chemical free as possible.
constipation It has been noticed since many 100 years ago that Dr. James Parkinson noticed that patients who later developed Parkinson’s disease have constipation brought before and in people who were born with the disease As constipation improves, Parkinson’s disease or symptoms also improve.
All emphasize taking care of the body, diet, eating and exercising, which, if done, will have a positive effect. From head to toe.
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