The most promising anti Covid treatments, today – time.news

by time news
from Gianluca Mercuri

Some doctors tout as effective therapies and remedies for which there is at best no evidence of efficacy available. This leads to a loss of confidence in drugs currently in development, at an advanced stage of testing. Here’s what they are

And they hide the treatments from us to sell the vaccines, and they boycott the treatments because the vaccines are expiring and they have to sell them, and they are all at the service of the pharmaceutical multinationals, politicians, doctors, journalists: all sold.

One of the most pernicious consequences of Covid, for those who had to deal with Covid for work reasons, was this: the sinister conspiracy, the nihilistic distrust of those who decide, care and inform, or at least try to do these three essential things in an initially uncertain context, struggling with a new and disturbing disease.

It extraordinary scientific result of a vaccine achieved in less than a year it was not enough: there is a segment of the population that, in any development, sees the confirmation of its own catastrophism. Evidently there is no reference to the physiological and entirely respectable “vaccination hesitancy”, because criminalizing instinctive fears would be criminal. We talk about the perennial angry that cures, or presumed such, have made the totem around which to dance in defense of the great taboo: no vaccine, never vaccine. The point is that science has never said that the vaccine renders treatment useless, and in fact he continued to look for them and also to find them.

Cure propagandate sui social

The point, in fact, is made as always by Enrico Bucci, a fine scientist and also a polemicist, who lists the right treatments but first that of the wrong curators: “The fact that some doctors, but above all many possessed on social networks, are touting as effective therapies and remedies for Covid-19, for which there is at best no evidence available of efficacy (and at worst there is evidence of non-efficacy), it is also serious because it leads to the loss of confidence in drugs currently in development – that is those antiviral treatments that have now reached an advanced stage of clinical trials“. These are below, explained one by one by the biologist.

Molnupiravir

“It is a prodrug, that is a molecule that, processed by our cells, is transformed into the active principle, that is, into a compound that is incorporated into the genome of RNA viruses during the replication process, causing”copy errors“Lethal. Originally studied for influenza, it was deemed promising by Merck, which, in partnership with its original owners, has now come into step 3, and the results of the extensive ongoing trial are expected by the end of this year. If it works, it will the first oral antiviral against Covid-19, to be taken within the onset of the first symptoms in order to make the disease less severe and shorter ». (Del Molnupiravir il Courier service had spoken since December 2020).

Pfizer

Even the multinational that is grinding billions with vaccines “is in development some interesting molecules, demonstrating the stupidity of those who say that drug research has stopped in the name of vaccines: first of all, a viral protease inhibitor for all betacoronaviruses (the family to which Sars-CoV-2 also belongs), provisionally named PF-07321332. In September, the phase 3 clinical trial also began for this compound, to be used in combination with the old antiviral Ritonavir in symptomatic patients before hospitalization; presumably the results will come early next year. At a slightly earlier stage, but still well within phase 2 of experimentation, a second Pfizer compound also arrived, the protease inhibitor prodrug PF-07304814. Originally identified as a compound with potential activity against SARS, it is in development as intravenous treatment in patients with more serious symptoms; also in this case, for definitive results we will have to wait until next year ».

Synairgen

The British company «has just started phase 3 for its interferon beta spray. Based on the fact that the Sars-CoV-2 virus benefits from the suppression of this interferon, which is useful for our immune system to block viral replication and improve the immune response, the company has developed a formulation of interferon beta capable of directly reach the lungs by inhalation, and has so far found good results in patients who are not too severe. We will see at the beginning of next year what the final results will be also in this case ». (By Synairgen il Courier service had spoken since September 2020).

The “miracle drugs” do not exist

In making this detailed survey, Bucci naturally warns that a comparison with the exceptional efficacy of vaccines would be misleading. The notion of “miracle drug” is a scoundrel oxymoron: the truth is that “antivirals that have an effectiveness even of only 50% – that is, that they achieve some results such as the abbreviation of the disease, the decrease in symptoms, the decrease in the risk of death, etc. – would already be a formidable result ». And then even the antivirals could sooner or later come across resistant variants. That said, having treatments that work in addition to vaccination prophylaxis would and will serve and how: «This is why we should pay attention to the experiments in progress, instead of Youtube or social networks».

September 29, 2021 (change September 29, 2021 | 21:54)

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