Paulo Fonseca takes a bold move by leaving Rafael Leao and Theo Hernandez on the Milan bench, with Emerson Royal and Youssouf Fofana starting against ambitious Lazio’s Taty Castellanos and Boulaye Dia.
It’s getting underway at the Olympic Stadium at 19.45pm UK time (18.45pm GMT).
You can follow all the build-up and action from today’s four Serie A games on the LIVEBLOG.
The Rossoneri have had a disastrous start to life under Fonseca, edging out a 2-2 draw with Torino and being soundly beaten by newly promoted Parma.
The coach takes radical measures, excluding Rafael Leao and Theo Hernandez, while summer signings Emerson Royal and Fofana make their debuts as starters.
Strahinja Pavlovic has also been confirmed, especially since Malick Thiaw is unavailable due to an ankle problem, and Alvaro Morata, Ismael Bennacer, Luka Jovic, Alessandro Florenzi and Marco Sportiello have also been added to the list of absentees.
With so few forwards, Francesco Camarda and Tammy Abraham, a new last-minute signing, are on the bench.
Lazio are also an evolving team under a new manager, beating Venezia in their opening game only to lose away to Udinese.
Luca Pellegrini joins Mario Gila on the operating table, but Marco Baroni brings big changes, including the ex-Salernitana duo Loum Tchaouna and Boulaye Dia on the pitch, as well as the first start of former Arsenal full-back Nuno Tavares.
Lazio vs Milan – where to watch the match on TV
The match is on Paramount+ in the US. Fans in the UK and Ireland can watch on TNT Sports 1 or OneFootball. beIN SPORTS 1 and the beIN SPORTS CONNECT streaming service are showing the Olimpico match live in Australia and New Zealand.
Lazio-Milan lineups
Lazio: Provedel; Lazzari, Patric, Romagnoli, Tavares; Guendouzi, Rovella; Chaouna, Dia, Zaccagni; Castellanos
Milano: Maignan; Emerson Royal, Tomori, Pavlovic, Terracciano; Reijnders, Fofana; Chukwueze, Loftus-Cheek, Pulisic; Okafor
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