2023-05-08 09:45:05
Spermidine is a natural compound located in our body, in fact, I am going to quickly answer your first question:
Yes, spermidine is called that because it is related to sperm; not because it is obtained from there (it is a hoax like taurine and bull semen), but because it was first found in human sperm, and researchers named it spermidine (a polyamine located in sperm). ; it was later found in many other living tissues.
In the body, it is located mainly on the ribosomes of cells. and regulates cellular processes important for cell survival and recyclingwhich in turn are closely linked to aging.
For this reason, and because it is a key molecule, it is considered spermidine as a natural fountain of youth.
Benefits and properties of spermidine
Spermidine is usually associated with a general purpose: The anti-aging effect.
This effect is achieved thanks to small influences on various processes in the body that make spermidine actually have an enormous capacity for action.
Protect your cardiovascular system
Spermidine is capable of increasing the bioavailability of Nitric oxideIn addition, it exerts a antioxidant functionblocks the production of proinflammatory cytokines and increases the phosphorylation of titin filaments in cardiomyocytes.
All this translates into:
- Reduces blood pressure.
- Increases the contraction-relaxation flexibility of cardiac tissue.
- Reduces arterial stiffness, improving endothelial function.
- Improves the mitochondrial function of cardiac cells.
Spermidine helps both our heart and blood vessels to function properly and not be affected by age-related tissue degeneration.
Activates cell regeneration: autophagy
Autophagy is the fundamental process that spermidine mediates and that has a large number of effects in the body, since, without going any further, a large part of the positive effects at the cardiovascular level that it has are mediated by autophagy and mitophagy processes.
Spermidine acts at various points in metabolic processes linked to autophagy. affecting histone methylation, increasing starvation response genes thanks to the blocking of Akt phosphorylation, and inhibiting the activity of EP300, an enzyme that blocks autophagy and whose inhibition directly induces the process.
Spermidine acts directly and indirectly on cell recycling processes that allow the body to get rid of those structures that are useless from a physiological point of view and that will only cause problems.
Protect your nervous system
Spermidine decreases the activation of T cells, which obviously reduces their reactive autoimmune response, which is closely linked to demyelination processes in neurons, which in turn catalyze neurodegeneration.
In the future, spermidine could be an adjuvant treatment for Alzheimer’s, since it is capable of coping with the processes that seem to be the triggers for this disease to manifest.
In addition, autophagy also occurs in neurons, increasing the neurological flexibility of the active zone of neurotransmitter exchange, increasing synaptic plasticity.
Modulates the immune system
Spermidine induces autophagy in CD8+ T cells, increasing the formation of T cell memory and may have a positive impact, for example, on the efficiency of a vaccination, or on the The body’s ability to generate antibodies to an infection to which it has been subjected.
It is also capable of generating changes dependent (and not dependent) on genomic transcription in macrophages that decrease T cell activation and the formation of proinflammatory cytokines, and may have a protective effect against the future development of autoimmune diseases.
Incredible true?
What foods contain spermidine?
Among all the sources of spermidine in the diet, one stands out, which is characterized precisely by not being a food part of any of the world’s diets, and by indirectly contributing to the diet, through preparations derived from this food: the wheat germ.
Wheat germ contains the largest amount of spermidine in food.
Other sources of spermidine, although with much lower concentration are:
- Soybeans and their fermented preparations, such as natto.
- The cured (old) cheese.
- Mushrooms.
- Walnuts.
- Peas and broccoli.
- Apples and pears.
Taking a high-quality supplement daily can help combat the specific age-related decline in spermidine, as intake from natural sources can vary significantly.
spermidine food supplements
The most efficient way to contribute meaningful content from spermidine to the diet is to use a quality food supplement.
In HSN You have a specific spermidine supplement that:
- Provides a high dose (2.5mg) per vegetable capsule.
- It is suitable for vegans and is extracted from natural sources (from wheat germ).
- It is not synthetic nor does it contain genetically modified organisms.
Spermedine 2.5mg from EssentialSeries.
Enjoy the best spermidine on the market with HSN’s manufacturing guarantees!
Bibliographic references
- Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018). Spermidine in health and disease. Science, 359(6374).
- Madeo, F., Bauer, M. A., Carmona-Gutierrez, D., & Kroemer, G. (2019). Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? Autophagy, 15(1), 165–168.
- Minois, N. (2014). Molecular basis of the “anti-aging” effect of spermidine and other natural polyamines – A mini-review. Gerontology, 60(4), 319–326.
Related Entries
- Do you know what Telomeres are and how they influence our youth? We tell you everything here.
- Why is vitamin E known as the “vitamin of eternal youth”? Find out at this link.
Where to find it – 100%
#supplement #properties #youth