2023-05-03 11:19:23
The drug is linked to a high risk of birth defects and developmental disorders in children exposed in utero
He valproic acid (sodium valproate), used to treat epilepsy or bipolar disordershould not be prescribed to women and girls of childbearing age due to the “high risk of birth defects and developmental disorders in children exposed in utero,” as warned by the world health organization (OMS).
Thus, the WHO experts recall that in women and girls of childbearing age lamotrigine or levetiracetam should be offered as first-line monotherapy for both generalized-onset seizures and focal-onset seizures.
Regarding women and girls of childbearing age who have already been prescribed valproic acid, the WHO indicates that it should be provided advice about the use of effective contraceptive methodswithout interruption, during the entire duration of the treatment.
“Information should also be provided on the risks associated with the use of valproic acid during pregnancy, prevention of pregnancy, and referral for counseling on anticoncepcin if they are not using effective contraception,” they added.
Likewise, it is necessary to evaluate the circumstances individual in each case when choosing the contraceptive method and involve the woman in shared decision-making.
If a woman is planning to get pregnanta person trained in the management of epilepsy/bipolar disorder in pregnant women should consider options alternatives of treatment. “Women should be informed to consult their physician as soon as they plan a pregnancy and of the need to consult urgently to your doctor in case of pregnancy”, they add in this regard.
One would also have to do “everything possible” for switch to alternative treatment adequate before conception. “If change is not possible, the woman should receive further counseling on the risks of valproic acid for the fetus, in order to support their informed decision-making.
A specialist should review periodically if valproic acid is the most appropriate treatment for the person”, they have riveted.
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