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Over the years, the pancreatic cancer it remains one of the most dangerous for those who suffer from it. The survival of patients who suffer from it is very low, around 10% five years after being diagnosed. Therefore, detecting it and knowing how to prevent it in time can be a factor that greatly conditions how it affects a person.
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This cancer usually develops as a result of what we know as pancreatic intraepithelial neoplasiaprecancerous lesions that form between 55 to 80% of adults over 40 years, according to some studies. Although these are low-grade in most cases, there are certain lifestyles that can activate them more frequently.
This is what a new study led by Imad Shireiqi and published in Nature Communications says. As they point out, precancerous lesions that have arisen in mice and humans contain elevated levels of a receptor sensitive to factors such as high fat diet.
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Study links pancreatic cancer to high-fat diet
This research considers that emerging precancerous lesions contain high levels of the transcriptional receptor delta activated by peroxisome proliferator PPARδ. This receptor regulates some genes involved in the fat metabolism and also in the formation of pancreatic cancer.
When PPARδ is activated, the progression of these lesions can be accelerated to become an active cancer, not only in the pancreas but also in other types of gastrointestinal cancer.
In addition, the study also investigates the involvement of a drug such as Cardarine (GW501516), associated with some sports supplements, which has also been shown to be an activator of PPARδ. This drug has been considered a risk factor since 1999 and, although its use is restricted, it continues to be used in some uncontrolled supplements.
However, at the moment there is very little information on this activator associated with pancreatic cancer, according to Shireiqi. Although the risk factors that can cause them are poorly defined and some of these lesions may not turn into cancer, being cautious and studying this type of lesion in time can be vital to counteract the lethality of pancreatic cancer. Therefore, this study determines that avoid a high-fat diet and drugs such as Cardarine could be decisive when it comes to activating PPARδ.ç
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