2023-10-06 12:22:17
Steroid hormones, specifically androgens and estrogens, influence the progression of canine triple negative inflammatory breast cancer (CMIC-TN), according to a study from the Complutense University of Madrid (UCM). This tumor subtype is one of the most aggressive with an incidence of 18% of breast cancers and a survival rate of one month from diagnosis in the clinic.
The work, carried out in mice, observes that a increased estrogen increases cell proliferation, favoring tumor growth. Furthermore, together with androgens, it promotes the migration or movement of cells through other tissues.
This tumor subtype is one of the most aggressive with an incidence of 18% of breast cancers.
Until now, this influence had been underestimated, since this type of cancer is characterized by not expressing some hormone receptors like the estrogen receptor. However, the UCM study has demonstrated the expression of a variant of this receptor (the beta subunit of the estrogen receptor) and another hormone receptor, the androgen receptor.
Therefore, this type of cancer is sensitive to hormonal therapies (anti-androgenic and anti-estrogenic). It has been observed that both anti-androgenic and anti-estrogenic treatments (dutasteride, anastrozole and ASP9521) produce a reduction in tumor viability, migration and size.
It has been observed that there is a regulation in the production of sex hormones and that hormonal imbalance produces an alteration in tumor development.
Juan Carlos Illera, researcher at the Faculty of Veterinary Medicine at the UCM
“In addition, it has been observed that there is a regulation in the production of sex hormones and that hormonal imbalance produces an alteration in the tumor development“, highlights Juan Carlos Illeraresearcher at the Faculty of Veterinary Medicine at the UCM and director of the study published in Research in Veterinary Science.
Application in humans and improvement of animal well-being
Another conclusion of this work is the possibility of extrapolating the results to the human species. “Numerous studies have supported that canine inflammatory mammary cancer shares many clinicopathological similarities with the same type of cancer in humans. “So not only can the treatment in dogs benefit from this study, but human patients, in the future, could have the possibility of improving the pathological response with an anti-hormonal treatment,” he adds. Belen Cresporesearcher at the Faculty of Veterinary Medicine at the UCM.
To carry out the study in the department of Physiology of the faculty, first of all studies were carried out in vitro among which stand out sensitivity tests to anti-hormonal treatments.
Not only the treatment in dogs can benefit from this study, but also human patients, in the future,
Belén Crespo, researcher at the Faculty of Veterinary Medicine at the UCM
Later, studies were carried out alive in which canine mammary tumors have been reproduced in Balb/SCID mice by inoculating the tumor cells and the same treatments have been applied as in the studies in vitro. With all the samples collected, immunoenzymatic assays were performed to determine hormonal levels both in the control and under treatment.
“In the future, anti-hormonal treatments could be applied to treat CMIC-TN and thus improve survival and survival.” well-being of dogs in the clinicsince anti-hormonal therapies lack the severe side effects that systemic chemotherapy produces, being better tolerated by the animal,” concludes Crespo.
Breast cancer in dogs accounts for between 50% and 70% of all tumors in non-neutered dogs. The prevalence increases in those countries where oophorectomy is not routinely performed. Furthermore, the survival rate in dogs with mammary cancer is 60% before reaching the first year of diagnosis.
Reference:
Crespo, Belén & Caceres, Sara & Silvan, Gema & Illera, Maria & Illera, Juan. “The inhibition of steroid hormones determines the fate of IPC-366 tumor cells, highlighting the crucial role of androgen production in tumor processes”. Research in Veterinary Science.
Fuente:
Complutense University of Madrid
Rights: Creative Commons.
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