2024-07-24 15:01:53
A group of Japanese scientists have developed small liver organs from cells that have, placed in mice, integrated into the original organ and help to repair fibrotic lesions. These damages, similar to arm in tissue, they are common to many liver diseases, such as fatty liver or cirrhosis. According to the authors, who published the results in the journal ‘Medicine Translational Science‘, these organoids may offer an alternative to liver transplants in the future.
This promising development suggests that organoids may be a viable alternative to all liver transplants in advanced liver diseases.
Liver fibrosis, which involves the formation of scar tissue, is common in chronic diseases such as cirrhosis. Currently, liver transplants are the only solution for end-stage cases, but the shortage of donors has fueled the search for new technologies.
The team brought about Tomomi Tadokoro, from Centro de Investigación Yokohama Shiritsu Daigaku Igakubu Daigakuinused induced pluripotent stem cells to create liver “sprouts,” which they then merge into large organoids.
When we go into the livers of mice with induced fibrosis, these organs manage to reduce fibrosis, showing a greater effect than individual fruits.
In addition, the organoids develop their own organs, such as bile ducts and blood vessels, that establish connections with the host’s liver. These findings open the door to possible treatments for cirrhosis in metabolic disorders, which will require additional studies to confirm their effectiveness.
The method involves using pluripotent iPS cells in mice to create ‘liver grafts’ that, once combined to form organs, are susceptible to transplantation into animals, improving liver function in animals with liver fibrosis of the chemical Matesanz, the founder of the National Connection Organization. “These liver organoids show a strong regenerative capacity, reduce fibrosis thanks to the activity of macrophages and are capable of forming their own organs such as bile ducts and blood vessels, as well as establishing connections with the original organism. of animals.”
In the sentences to Science Media Center, Matesanz, notes that the line of research proposed in this article can become revolutionary since, if it is done in all its terms and can be applied to the clinic, it will mean having an effective treatment for liver fibrosis, which it is the final common path. of many liver diseases. It will, therefore, represent a solution for thousands of patients without access to a transplant.
«Supply/demand imbalance is a universal phenomenon in all types of transportation, but it is sad especially in the case of the liver because it is the most demanded after the kidney and because, unlike the kidney, it does not have other alternatives like dialysis and, therefore, is important in nature. For this reason, liver transplantation is today the only solution to all types of terminal liver diseases.
Matesanz warned that with the caution involved in being studied in experimental animals and pointed to a specific method of experimental liver disease, “This line of research, which follows previous work by the same group with a strong track record, opens a path. with great opportunities in finding alternative ways to transport and thus reducing the shortage of organs.
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