Dr. Anan Chongkaewwatana, virologist Director of Animal Health and Management Innovation Research Group National Center for Genetic Engineering and Biotechnology (Biotech), National Science and Technology Development Agency (NSTDA) posted a message via Facebook Anan Jongkaewwattana stated that …
Unlike the monkey pox virus, the genetic material is DNA. SARS-CoV-2, which is RNA, is much more difficult to change in DNA than RNA, causing these viruses to have a slow genetic sequence. Usually only about one change is found per year. But the results of genetic sequencing analysis of the monkey pox virus, which is now spreading in many countries, found that It differs from the virus that was isolated when jumping from animals to humans four years ago in 40 locations in the UK, Singapore and Israel. If the change is natural We estimate that there will be only 4-5 positions difference between these different periods. Shows that the virus is spreading in many areas now. It is up to 10 times faster than normal viruses.
No one currently has a definitive answer as to what will happen to the monkeypox virus 2022 (let’s call it MPXV-2022), but there are some interesting hypotheses. Personally, I agree and I think there is an interesting point. Virus decryption results MPXV-2022 A 40-position change showed that the changes were uniform: GA was changed to AA and TC was changed to TT, which was very specific, not random or continuous. This change in appearance is mainly due to The virus’s self-transition escapes the host mechanism. Usually the host has an enzyme that acts to capture the virus’s sequence and change it. causing mutation in the genetic material of the virus Changed so much that the virus could eventually lose its ability to multiply itself. This enzyme (named APOBEC) in each host species binds to a different base sequence. of rats caught one of people, they catch one thing that is not the same The virus itself must have a way to coexist with the host. One way is to change the location of the host’s APOBEC to another to escape detection by the enzyme. This is a self-transformation mechanism that allows the evolution of that virus to exist with the host. Usually such changes take a long time.
The interesting point is that the GA and TC at MPXV-2022 have 40 changes. To deal with that virus, MPXV-2022 changes its location in this specific way. It may be the mechanism by which the virus tries to escape the capture of human enzymes to survive in the new host. causing many researchers to hypothesize that It’s possible that MPXV-2022 has been around in the human population for quite some time. The virus may have modified the host from an intermediary animal to a person. This makes it easier to spread from person to person.
It must be reiterated that It is a hypothesis that has been analyzed from the genetic sequence of the virus. Virus isolation data are not available to compare the proliferation properties of human cells with older strains. How are they different? Which I believe will have to be analyzed soon.