Weight fluctuates periodically… Increases risk of ‘early dementia’ in middle age

Ryu Ji-won, Seoul National University Bundang Hospital research team, results of 3.6 million health checkups

Jiwon Ryu, professor at the Hospitalization Center at Seoul National University Bundang Hospital (left) and Hyeongjin Yoon, professor at the Department of Biomedical Engineering at Seoul National University Hospital (right), conducted a study that found that weight fluctuates frequently in middle age and that if the fluctuation range is large, the risk of developing early dementia increases. The results were released (provided by Seoul National University Bundang Hospital)/

A study found that weight frequently fluctuates periodically in middle-aged people, and that if the fluctuation range is large, the risk of developing early dementia increases.

The research team, Professor Ryu Ji-won of the Hospitalization Center at Seoul National University Bundang Hospital and Professor Yoon Hyeong-jin of the Department of Biomedical Engineering at Seoul National University Hospital, analyzed the data of over 3.6 million people in Korea who underwent health checkups between the ages of 40 and 65 registered in the National Health Insurance Corporation data, and analyzed the data of over 3.6 million people who underwent health check-ups between the ages of 40 and 65 in Korea. The results of a study on the relationship between the so-called ‘weight cycle’ and the development of early dementia were presented on the 4th.

According to the research team, sudden weight changes after middle age can be considered a red flag for health. It is known that rapid weight gain or loss is closely related to various serious diseases such as cancer, cardiovascular disease, diabetes, decreased immunity, osteoporosis, and cognitive disorders such as dementia, and the greater the weight fluctuation, the higher the mortality rate.

The research team used data from 10 years of follow-up of patients who had been examined more than 5 times at 1-2 year intervals, and determined the range of weight cycle fluctuations as △3% or more △5% or more △7% or more △10% or more compared to previous weight. The analysis was divided into four sections.

As a result, the risk of developing dementia in patients who experienced cycles of weight fluctuation of 3% or more increased 1.2 times compared to the normal group with weight fluctuations of less than 3%, and rose steeply to 2-fold in cases of 10% or more. The average age of onset is 58, which is the age group for early dementia.

Additionally, if you experience two or more weight cycles with weight fluctuations of 10% or more during the 10-year follow-up period, the risk of dementia increases by 2.5 times, and if your BMI (body mass index) is higher than 25, the risk of weight fluctuations increases further. Confirmed.

The results of this study suggest that larger and more frequent weight cycles, such as the yo-yo effect of losing and gaining weight or gaining and then rapidly losing weight, can have a negative impact on brain health and increase the incidence of early dementia.

Professor Ji-won Ryu said, “This is a research result that raises awareness about weight management. Excessive fluctuations in body weight can have negative effects on the human body, such as metabolic stress. Therefore, in middle-aged and older, the focus should be on stably managing the weight so that it does not fall outside the appropriate range.” “There is a need for both,” he emphasized.

Meanwhile, the results of this study were published in the international academic journal ‘Alzheimer’s Research & Therapy’.

(Seoul = News 1)

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2024-10-04 12:20:08