When the brain gets tired, glutamate builds up

Studied since the end of the 19th century, cognitive fatigue remains poorly understood and the mechanisms responsible for it are still not known. baranq – stock.adobe.com

DECRYPTION – The French researchers who have just made this discovery are still wondering if this is what degrades our cognitive abilities.

You have been working on a file for several hours and you are starting to accumulate errors; you’re on the second candy bar and you’ve just yelled at a co-worker. All these signs confirm it: your brain is tired and your cognitive control drops significantly. Studied since the end of the XIXe century, cognitive fatigue remains poorly understood and the mechanisms responsible for it are still not known. A French research team recently published in the scientific journal Current Biology results that shed new light on this phenomenon.

“Until now, there were two types of hypotheses to explain this fatigue. The functional theory considers that fatigue is a signal from the brain to stop the strenuous activity in order to turn to a more pleasant activity. explains Mathias Pessiglione, research director at the Brain Institute (ICM – Hôpital de la Salpêtrière) and responsible for this project. “But the…

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