2.Strains BA.4 and BA.5 will cause symptoms ofCOVID-19 more seriousOh Micron Are the subspecies “BA.1” and “BA.2” currently epidemic?
From the examination of the whole genome of the coronavirus 2019 virus from the Global Covid-19 Database “GISAID”, “10,220,862 samples” from around the world were found.
-Strain BA.4 approximately “83 specimens” and
– Species BA.5, only “37 samples”, which does not reach the hundreds digits, making the speculation that Both virus strains may have evolutionary trajectories that are currently incompatible with the environment.
from searching the World COVID Genetic Code Database “GISAID” On 4/12/22, BA.4 and BA.5 have not been found in Thailand (Picture 3)
It concluded that WHO is currently monitoring six subspecies of omicron: BA.1, BA.1.1, BA.2, BA.3, BA.4 and BA.5) and approximately 8 hybrids. The species are XD,XF, XE, XG,XH,XL,XK, and XJ (Picture 2).
The BA.4 and BA.5 strains are genetically coded very similar to Omicron “BA.2”, with approximately two different mutations from Omicron BA.2 on the spiny segment, L452R, which is identical to the delta and lag. Mpda and F486V, which are rarely found in other variants.
The study of mutations that alter the spines was urgently needed to understand the immune evasion effects of these two new virus strains.
Incidentally, coronavirus 2019 has mutations all the time but only “Only certain mutations” can affect a virus’s ability to spread or evade immunity previously acquired through vaccination or natural infection. including affecting the increase or decrease in the severity of COVID-19
For example, the case of BA.2, which is 94 percent of the time globally, is more contagious than all previously infected strains of the 2019 coronavirus (except BA.4 and BA.5), but the evidence so far. This suggests that BA.2 is unlikely to cause severe disease as in the past delta beta alpha.
The UK’s Health Security Agency, which deciphers the whole genome of COVID-19 from global samples (whole genome sequencing), said last week that BA.4 was found in South Africa, Denmark. Botswana, Scotland and England from 10 Jan. to 30 Mar.
The BA.5 strain last week is still found only in South Africa. But on Monday, Botswana’s Ministry of Health reported that four BA.4 and BA.5 cases, aged 30-50, have been fully vaccinated. with mild symptoms
Thank you Center for Medical Genomics