2023-12-12 08:14:49
The new active ingredients against obesity are administered using a pen. Image: picture alliance / NurPhoto
For many people, semaglutide and tirzepatide help them lose weight. But as soon as the injections are stopped, a rebound effect occurs. How doctors want to deal with it.
The hopes for the new weight loss injections are high: Obese people can use them to lose a lot of weight, just one prick a week is enough. The drugs create an artificial feeling of satiety in the brain and thus inhibit appetite. In some cases, obese people lose a quarter of their body weight with these injections. But as impressive as the successes during therapy are, what patients experience after stopping the injections is sobering: they gain weight again, and significantly so.
Pia Heinemann
Editor responsible for the “Science” department.
This so-called rebound effect has already been scientifically described in the past for semaglutide, which has been approved in Germany since the summer. Now shows a study, which a team led by Louis J. Aronne from Weill Cornell Mecial College in New York published in the journal “JAMA”, also found a similar effect for tirzepatide. The active ingredient has not yet been approved in Germany for the treatment of obesity, but in studies it is significantly more effective than semaglutide. The researchers now investigated whether the rebound effect also occurs after tirzepatide is discontinued.
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