BEVERLY HILLS, Calif., Jan. 11, 2026 – Nikki Glaser‘s return to hosting the Golden Globes on Sunday night was, to put it mildly, a masterclass in fearless comedy. The comedian, back for a second year, didn’t shy away from roasting Hollywood’s elite, and she made it clear upfront: weight loss drug jokes are officially over.
Glaser’s Globes: No Ozempic Talk, Plenty of Star-Studded Sass
The comedian delivered a sharp, self-aware monologue, tackling everything from George Clooney’s skincare routine to the DOJ’s handling of the Epstein files.
Before taking the stage, Glaser told reporters she’d moved past the easy jokes about popular weight loss drugs. “Ozempic’s been done,” she said. “Some jokes there’s just not a unique way to do them anymore.” That commitment to fresh material was evident throughout her opening monologue.
What makes a good Golden Globes monologue? Glaser seemed to answer that question herself, delivering a rapid-fire series of observations that were both biting and affectionate. She opened with a playful jab at the event’s importance, declaring it “without a doubt the most critically important thing that’s happening in the world right now.”
The comedian didn’t hold back, aiming her wit at a wide range of celebrities. she joked about Warner Brothers’ financial state, quipping, “we’ll start the bidding for Warner Brothers at five dollars. Do I hear five dollars?” She then turned her attention to the star-studded audience, playfully teasing George Clooney about his seemingly eternal youth. “You’re so good,” she said. “I’m such a fan I shouldn’t be allowed to talk to you right now.” She even asked him for help troubleshooting her nespresso machine.
Leonardo DiCaprio also found himself in Glaser’s crosshairs. She joked about his career longevity and his penchant for dating younger women, adding, “You were able to accomplish all of that before your girlfriend turned 30. I mean it’s just insane.” She quickly apologized, acknowledging the joke was “cheap” and admitting she couldn’t find much else to say about the actor. “Like open up!” she urged. “The most in-depth interview you’ve ever given was in Teen Beat magazine in 1991.”
The monologue wasn’t limited to Hollywood gossip. Glaser also referenced current events, making a pointed remark about the Justice Department’s handling of the Epstein files and even throwing a playful jab at CBS News while *on* CBS. “CBS News – America’s newest place to see BS news,” she quipped.
Glaser’s performance was a refreshing blend of irreverence and affection, proving once again why she’s one of the most sought-after comedians in the industry. She closed her monologue with a heartfelt message to the nominees, encouraging them to continue pushing boundaries and creating innovative work. “Your work this year was innovative, it felt fearless, inspiring, and in some cases, downright Zootopian,” she said. “Just please keep doing what you’re doing.”
“I love you guys! Thank you so much,we have a great show for you tonight!”
