Here are three boxes, formatted as requested, to insert into the article. Placement suggestions follow after the boxes.
Placement Suggestions:
* the “Did you know?” box would fit well after the first paragraph, promptly following the introduction of the heartbreaking experience of losing recognition.
* The “Pro tip” box could be inserted after the paragraph discussing the deterioration of PNNs, offering a proactive step readers can consider.
* The “Reader question” box would be appropriate after the paragraph detailing the use of MMP inhibitors in mice, expanding on that research.