2023-08-21 14:45:27
A new study from the PhyloBone project identifies hundreds of non-collagenous bone matrix proteins that could play regulatory roles in bone formation and regeneration. The study opens the door to new treatments and preventive measures for bone regeneration and osteoporosis research.
The PhyloBone project uses a novel approach, based on the principles of evolutionary biology, to study bone formation, which will substantially contribute to the identification of molecular mechanisms and new therapeutic targets, as indicated by Dr. Pere Puigbò, from the University from Turku in Finland, one of the principal investigators of the PhyloBone project.
Osteoporosis is one of the most common bone problems in the elderly population worldwide. Approximately 9 million fractures per year, on average one every three seconds, are caused by osteoporosis, which contributes significantly to morbidity and mortality rates in developed countries. As life expectancy is increasing globally, osteoporosis has become a growing concern as it significantly affects the quality of life for people in most countries.
Since the bone matrix plays both structural and regulatory roles, non-collagenous organic components play a key role in bone regulation. Although some non-collagenous proteins, such as osteopontin, are known to play an important role in bone formation, the bone matrix proteome is composed of hundreds of little-studied proteins that may play important regulatory roles in bone regeneration and repair. osteoporosis.
Some of the bones of a hand and wrist, seen through an x-ray. (Photo: CDC)
The PhyloBone project has identified 255 proteins in 30 vertebrate species.
The goal of the PhyloBone project is to serve as a valuable resource for future research in the areas of bone regeneration, osteoporosis, and related fields.
Margalida Fontcuberta-Rigo, Pere Puigbò and Miho Nakamura, all three from the University of Turku, present the technical details of the work carried out so far in the academic journal Bone Research, under the title “Phylobone: A comprehensive database of bone extracellular matrix proteins in human and model organisms”. (Source: University of Turku)
#Bone #regeneration #osteoporosis #proteins