2023-10-23 12:12:00
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A group of researchers from the Autonomous University of Barcelona (UAB) together with the University of Washington has made a discovery that could improve the quality of life of millions of people.
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The team led by researcher Albert Quintana has revealed the mystery behind motion sickness, a common but no less disabling problem that affects numerous people in situations as varied as traveling in a vehicle or experiencing virtual reality. The study, which Has been published in the prestigious magazine PNASnot only reveals the neurons responsible for this phenomenon but also opens the door to much more effective treatments.
VGLUT2 neurons
Dizziness is a complex sensation, and scientists have managed to identify that VGLUT2 neurons in the inner ear are at the center of this intricate process. These neurons are vital for maintaining our balance and posture.. The study has managed to elucidate how these neurons interact with other systems in our body to create the sensation of dizziness, especially when there is a discrepancy between what our eyes see and what our body feels. A common scenario is being in a moving vehicle while seated, which can cause conflicting signals resulting in motion sickness.
The connection between VGLUT2 neurons and a hormone called cholecystokinin (CCK) has been a particularly intriguing find. CCK not only plays a role in digestion and appetite, but it is also activated during episodes of dizziness, which can result in vomiting. This mechanism, although uncomfortable, has been crucial in human evolution to avoid ingesting spoiled food. However, in the modern world, this ancient reaction can be more of a hindrance than a help, especially in transportation or virtual reality.
Devacepida: a promising drug
The proposal of a new drug, devacepid, is one of the most promising ramifications of this study. This drug, already approved in Europe and the United States for gastric problems, has the potential to block the action of CCK and therefore relieve motion sickness. Through experiments with mice, researchers have demonstrated the effectiveness of devacepide, which unlike existing treatments, does not have side effects such as drowsiness.
The work of Quintana and his team marks a milestone in neuroscience and medicine, offering hope for those who suffer from chronic dizziness or those who face these challenges in everyday situations. Additionally, he opens a door to explore how other systems in the human body are interconnected in ways we do not yet fully understand.
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