2024-07-09 08:45:41
Scientists have managed to identify the molecular profile of patients with rheumatoid arthritis who have a higher heart risk.
Rheumatoid arthritis is an autoimmune disease of unknown origin that affects around 18 million people worldwide, according to data from the World Health Organization. It produces chronic inflammation that affects the joints, but beyond that, and among other consequences, it can increase the probability of suffering from heart disease by 50%.
A new study by the University of Córdoba (UCO), the Maimónides Institute for Biomedical Research (IMIBIC) and the Rheumatology service of the Reina Sofía University Hospital of Córdoba (HURS), in Spain, all institutions these works, have managed to establish, for the first time, the molecular profile of patients with rheumatoid arthritis who have a higher risk of suffering cardiovascular events.
To do this, the group, which is among others, Laura Muñoz-Barrera from UCO and Alejandro Escudero from IMIBIC, has analyzed the blood samples of more than 300 people with this disease, in which the study more than 30 different substances related to oxidative stress, the transformation of immune cells and other inflammatory cells such as things called cytokines.
In this way, using computational tools and bioinformatic techniques that have cross-referenced more than ten thousand different data, the program has managed to organize three different groups of patients who share the same criteria similar based on all of these molecular characteristics previously examined.
Chary López-Pedrera, the first researcher of “Automotive Diseases explains that once we have investigated the clinical characteristics of each of these three groups, we have decided that, in particular, one of them is more likely to develop heart and blood diseases,” “group. chronic inflammatory diseases of the musculoskeletal system and connective tissue”. To do this, the research team analyzed different parameters associated with a greater risk of heart problems such as hypertension, obesity or thickening of the carotid intima-media, the two inner layers of the artery responsible for supplying blood to mental.
Carlos Pérez-Sánchez, Ramón y Cajal researcher, and member of the Department of Hematology, Physiology and Immunology from the University of Córdoba. “We have been able to describe this is a result that should, in the future if it is approved, the recommendation of certain materials can provide information about the possibility of suffering a heart problem,” he adds.
Researchers Chary López-Pedrera and Laura Muñoz, together with researcher Carlos Pérez, have IMIBIC facilities. (Photo: IMIBIC/UCO)
In this way, the study shows progress to new, more specific and personalized medical treatments, a scenario that can be done in the future, through a blood test, to identify patients who, despite suffering from the same disease , in contrast. characteristics that can be addressed in therapy in a different way.
The study, coordinated by UCO, IMIBIC, and HURS Rheumatology Service, also has the collaboration of other hospitals located in Santander, Seville, Malaga and Jaén, within Spain.
The study is titled “Assessment of subjective cardiovascular risk in Rheumatoid Arthritis patients using circulating molecular profiles and their modification by TNFi, IL6Ri, and JAKinibs.” And it has been published in the academic journal Biomedicine & Pharmacotherapy. (Source: UCO)
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