2024-04-06 02:20:19
Multiple sclerosis has several types. No two cases of this disease are exactly alike.
Diffuse sclerosis is characterized by a huge diversity of the clinical course of the disease, its clinical manifestations and the outcome of the disease, which is due to the different location of the foci of demyelination in the optic nerves, cerebral hemispheres, spinal cord, and cerebrum.
The following forms of the clinical course of the disease are described:
1. Primary progressive multiple sclerosis
2. Secondary progressive multiple sclerosis
3. Attack course of multiple sclerosis
4. Clinically isolated syndrome
In primary progressive multiple sclerosis, 10% of patients initially have a progressive and persistent development of neurologic symptoms. This progression (advancement of the disease or constantly aggravated state) is rarely interrupted, and the improvement is insignificant, that is, the patient is in a phase of continuous exacerbation, which very quickly leads to the development of disability. Hence the name of this form, primary progressive.
This type of multiple sclerosis is most common in people over the age of 40, affecting women and men equally.
The most common symptom of this type of multiple sclerosis is progressive weakness of the lower limbs, which occurs in 80% of cases of primary progressive multiple sclerosis.
The second most frequent symptom is loss of balance and balance, which occurs in 15% of cases and is a consequence of diffuse cerebellar involvement.
Despite the pronounced disability, in patients with primary progressive multiple sclerosis, changes in magnetic resonance imaging (MRI) are much less pronounced than in other subtypes of Multiple Sclerosis, the foci tend to be smaller, but it is impossible to differentiate the subtype of Multiple Sclerosis by MRI images alone.
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