Dr. Anan Chongkaewwatana, virologist Revealing the sequencing analysis of the viral hypothesis. The monkey pox virus has genetic material in DNA, which is different from the coronavirus. and can change 10 times faster than normal virus
Today (30 May) Facebook “Anan Jongkaewwattana” or Dr. Anan Jongkaewwattana, a virologist Director of Animal Health and Management Innovation Research Group The National Center for Genetic Engineering and Biotechnology (Biotech), National Science and Technology Development Agency (NSTDA) posted a message saying, “The monkey pox virus contains genetic material in DNA, which is different from the coronavirus. or SARS-CoV-2, which is RNA, the change in DNA is much more difficult than RNA, causing these viruses to have a slow genetic sequence. Usually only about one change is found per year. But genetic sequencing analysis of the monkey pox virus, which is now prevalent in many countries, shows that it is 40 different from the virus isolated when jumping from an animal four years ago in the UK, Singapore and Israel. Originally believed that if the change was natural We estimate that there will be only 4-5 positions difference in the time difference. It shows that the virus that has spread in many areas is now changing 10 times faster than normal virus.
No one currently has a definitive answer as to what will happen to the monkeypox virus 2022 (let’s call it MPXV-2022), but there are some interesting hypotheses. which I personally agree and think there is an interesting point In transcriptional results of MPXV-2022 virus transcription, 40 changes were found to be homologous: from GA to AA and from TC to TT, it is highly specific, not random. or keep changing This type of alteration is primarily caused by the virus escaping the host mechanism. Usually the host has an enzyme that acts to capture the viral base sequence and change it. cause mutation in the virus’s genetic material to change a lot. Until eventually the virus can’t go on and eventually loses its ability to multiply. This enzyme (named APOBEC) in each host species captures a different base sequence. of rats caught one of people, they catch one thing that is not the same The virus itself must have a way to coexist with the host. One way is to change the location of the host’s APOBEC to another to escape detection by the enzyme. which is a self-transformation mechanism that causes the evolution of that virus to survive with the host Usually such changes take a long time.
The interesting point is that the GA and TC at MPXV-2022 have 40 changes. To deal with that virus, MPXV-2022 changes its location in this specific way. It may be the mechanism by which the virus tries to escape the capture of human enzymes to survive in the new host. causing many researchers to hypothesize that It’s possible that MPXV-2022 has been around in the human population for quite some time. The virus may have modified the host from an intermediary animal to a human. This makes it easier to spread from person to person.
Again, it must be emphasized that the hypothesis was analyzed from the genetic sequence of the virus. Virus isolation data are not available to compare the proliferation properties of human cells with older strains. How are they different? Which I believe will have to be analyzed soon.”