2024-10-24 14:53:00
Semaglutide, the popular diabetes and weight loss drug, may also reduce the risk of Alzheimer’s disease in people with type 2 diabetes.
A study of Case Western Reserve College of Medicine who compared this popular drug with seven other anti-diabetic drugs. The study, published in the journal “Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association.”‘, suggests that patients with type 2 diabetes who take semaglutide have a significantly lower risk of developing Alzheimer’s disease. These findings were consistent across different subgroups, including obesity status, gender, and age.
Alzheimer’s disease is a brain disease that slowly destroys memory and thinking skills.
THE semaglutidea glucagon-like peptide receptor (GLP-1R) molecule that decreases hunger and helps regulate blood sugar in type 2 diabetes, it is also the active ingredient in diabetes and weight loss medications Wegovy y Ozempic.
The research team, led by professor of biomedical informatics Rong Xuanalyzed three years of electronic data from nearly one million American patients with type 2 diabetes. The researchers used a statistical approach that mimics a randomized clinical trial.
They found that patients who were prescribed semaglutide had a significantly lower risk of developing Alzheimer’s disease, compared to those who took any of seven other diabetes drugs, including other types of drugs targeting the GLP-1R.
Neurodegeneration
“This new study provides real-world evidence of its impact on Alzheimer’s disease, although preclinical research has suggested that semaglutide may protect against neurodegeneration and neuroinflammation,” Xu notes.
Although their results potentially support the idea semaglutide could prevent Alzheimer’s disease, study limitations prevent researchers from reaching definitive causal conclusions.
“Our findings indicate that further research into the use of semaglutide through randomized clinical trials will be needed to test alternative drugs as a possible treatment for this debilitating disease,” says Xu.
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