2023-07-18 17:45:01
It is known that in a small percentage of patients with gastrointestinal tumors there are genetic alterations that significantly increase the appearance of tumors. Knowing them can allow applying personalized treatments when they appear, and most importantly, establishing strategies for their early diagnosis or to prevent their appearance. This is particularly important in tumors where the response to cancer treatment is lower in advanced stages, such as pancreatic cancer or gastric cancer.
The development of technology and the reduction in cost of it are leading to a revolution in oncology. Specifically, at present, multiple genes can be studied at the same time (gene panels) at an increasingly reduced economic cost with the aim of identifying hereditary syndromes that increase the risk of cancer.
In this sense, experts from the Spanish Association of Gastroenterology, the Spanish Society of Medical Oncology, the Spanish Association of Human Genetics and the IMPaCT-Genomics Consortium have established a consensus whose objective is to establish recommendations for the use of multigene panel tests in patients with gastrointestinal and pancreatic cancer.
The team is made up of, among others, Sabela Carballal from the Hospital Clínic de Barcelona, and Luis Bujanda, from the University of the Basque Country (UPV/EHU)).
The Dr. Louis Bujanda. (Photo: UPV/EHU)
The document includes recommendations on clinical scenarios in which multi-gene panel testing is recommended in different situations such as people who have had colorectal cancer, in patients who have multiple colon polyps, in patients with gastric and pancreatic cancer, as well as the genes to consider in each clinical scenario. Recommendations are also made about the relevance, or not, of performing genetic studies with gene panels in healthy people who are concerned about a family history of cancer in their family.
The document is entitled “Use of multi-gene panels in patients at high risk of hereditary digestive cancer: position statement of AEG, SEOM, AEGH and IMPaCT-GENOMICS consortium”. And it has been published in the academic journal Gastroenterology and Hepatology. (Source: UPV/EHU)
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