New Test detects ’Zombie Cells’ as Early Sign of Lung Cancer
A groundbreaking study has revealed a new test capable of identifying "zombie cells" in urine – potentially offering an early warning sign of lung cancer.
This innovative test comes at a crucial time: in 2023 alone, 1696 men and 1623 women were diagnosed with lung cancer in Norway, leading to 2142 deaths.
The research focuses on proteins secreted by these "zombie cells." These atypical cells,while alive,have lost the ability to divide. They can damage tissues by reprogramming their surrounding environment, potentially contributing to the development of cancerous cells.
The new test uses an injectable sensor that reacts with these proteins, allowing scientists to detect them in urine and signal the presence of zombie cells.
Ljiljana Fruk, the study’s lead author, explains, "We have developed a test based on proteins that break down peptides, and which are found at higher levels in the presence of zombie cells.These proteins appear early in cancer development, allowing for detection before symptoms emerge."
the researchers are also exploring the potential to adapt this test for other types of cancer. Fruk states, "We are nearing completion of a functional urine test to detect these zombie cells in lung cancer, which will allow for earlier detection and avoidance of invasive procedures. This also has potential applications for other cancers."
A Step Towards Earlier Cancer Detection
Sigrid bratlie, a molecular biologist, believes this could be a game-changer for cancer treatment.
"If this holds true, it’s groundbreaking," she says, "Zombie cells are a very engaging approach, but how accurately they predict cancer is crucial. These researchers believe they are a direct indicator of cancer, but further research is needed. While zombie cells naturally occur as we age, not everyone develops cancer," she explains.
With the rapid advancements in cancer research,blood tests have emerged as a promising avenue for early detection. The UK government is heavily investing in research for a blood test capable of identifying the 12 most common cancers.
Bratlie notes,"Both blood and urine tests aim for early diagnosis of cancer. Blood tests analyze DNA from circulating cancer cells, detecting specific cancer mutations. While promising, it remains unclear if these tests can accurately distinguish between cancer cells that will become active and those that won’t," she concludes. "Though,these advancements are notably crucial for cancers with low survival rates and where early detection is challenging."
How does the new urine test for lung cancer compare to traditional blood tests?
Interview: Groundbreaking Test for Early Lung Cancer Detection with Ljiljana Fruk and Sigrid Bratlie
Time.news Editor: Today, we have the privilege of discussing an exciting advancement in lung cancer detection with Ljiljana Fruk, the lead author of a groundbreaking study on “zombie cells”, and Sigrid Bratlie, a molecular biologist who is closely following developments in this field. Thank you both for joining us.
Ljiljana Fruk: Thank you for having us.
Sigrid Bratlie: It’s a pleasure to be here.
Time.news Editor: Ljiljana, can you explain what “zombie cells” are and why they have become the focus of this new urine test?
Ljiljana Fruk: Absolutely. “Zombie cells” are a type of damaged cell that, while still alive, have lost the ability to divide. They pose a risk because they can damage surrounding tissues by altering their environment, which can lead to the development of cancerous cells. Our research has identified specific proteins secreted by these cells that are present at higher levels during the early stages of cancer, making them crucial for detection.
Time.news Editor: This is captivating. The statistics from Norway show such a notable number of new lung cancer cases and deaths. How does this new test change the landscape for early cancer detection?
Ljiljana Fruk: Our test is designed to detect these specific proteins in urine, using an injectable sensor that reacts to them. This could allow for earlier detection of lung cancer before symptoms appear, ultimately leading to better patient outcomes and potentially reducing the need for more invasive diagnostic procedures.
Time.news Editor: Sigrid, from a molecular biology standpoint, how significant is this research for the future of cancer treatment?
Sigrid Bratlie: If this test proves reliable, it could indeed be groundbreaking. The use of “zombie cells” as indicators of cancer progression is very innovative; however, we must ensure that these cells accurately predict cancer. Since zombie cells occur naturally with age, there’s a risk of false positives. We need further research to understand the correlation between the presence of zombie cells and the actual development of cancer.
Time.news Editor: That’s a critical point, Sigrid. How does this urine test compare with existing blood tests for early cancer detection?
Sigrid Bratlie: Both urine and blood tests have their merits in early cancer diagnosis. Blood tests typically analyze DNA from circulating cancer cells to detect mutations. However, distinguishing between cancer cells that are likely to become active and benign ones remains challenging. Urine tests that focus on proteins from zombie cells offer a complementary approach, especially for cancers that are challenging to detect early.
Time.news Editor: Ljiljana, are there plans to adapt this test for other forms of cancer as well?
ljiljana Fruk: yes, we are actively exploring the potential for this test to be adapted for other types of cancer. The hope is that we can create a more comprehensive early detection framework that could benefit a wide range of patients.
Time.news Editor: This is unbelievable news. For our readers who may have concerns about lung cancer or are curious about their own health, what practical advice can you offer?
Sigrid Bratlie: I encourage regular check-ups and discussions with healthcare providers about any changes in health or risk factors. Early detection is key, and being proactive can lead to better management of your health.
ljiljana fruk: I agree. staying informed about new advancements in cancer detection can empower individuals. If you have risk factors for lung cancer,it’s important to talk to your doctor about screening options.
Time.news Editor: Thank you, Ljiljana and Sigrid, for sharing your insights on this transformative approach to early lung cancer detection. It’s inspiring to see how research is paving the way for a healthier future.
Ljiljana Fruk: Thank you for having us.
Sigrid Bratlie: It was a pleasure to discuss this critically important topic.