A drug for prostate cancer opens a new way to treat Parkinson’s

2024-02-09 12:43:56
From the moment a patient ingests a drug until it leaves the body, the medication goes through several biotransformation processes where the body discards what is unnecessary and keeps what interests it in the body. Before disappearing, the drug performs its function, but what remains is called a metabolite, and its biological activity may be different from that of the original drug. And the most relevant thing: a drug and its metabolites, together in the body, can cause completely different effects than the individual molecules. This is the case of Rucaparib, a drug used in chemotherapy for ovarian cancer, breast cancer and, more recently, prostate cancer, and its metabolite, the M324 molecule. Now, a new study led by Catalan researchers from the CSIC has shown that Rucaparib and its main metabolite may be key to treating Parkinson’s patients. Related News standard No A patient with Parkinson’s walks normally again thanks to a neuroprosthesis R. Ibarra standard Yes INTERNATIONAL CANCER DAY Cancer at 30: «It affects healthy people who take care of themselves, eat well and do sports. What is happening? Nuria Ramírez de Castro The work – published in the journal ‘Cell Chemical Biology’ – has been carried out by making a computational prediction of the activity of the metabolite M324, where they have found that it is capable of reducing the accumulation of the protein a-synuclein (a component important Lewy bodies), in neurons derived from Parkinson’s patients, a neurodegenerative disease characterized by a movement disorder, and in which neurons do not produce sufficient quantities of the neurotransmitter dopamine. The fact that M324 is capable of reducing the abnormal accumulation of a-synuclein in neurons derived from stem cells of a Parkinson’s patient “highlights the therapeutic potential of this metabolite and its possible pharmacological application for the treatment of this disease.” , indicates the study. In fact, the synergy demonstrated between Rucaparib and M324 in prostate cancer cell lines has already had an impact in clinical trials for advanced stages of this type of cancer. Desktop Code ????An anticancer drug opens a new path for the treatment of Parkinson’s. ????The results of researchers from @idibell_cat @ICO_oncologia and @IQAC_CSIC open the door to rethinking the use of drugs and their metabolic products in personalized medicine. ???? pic.twitter.com/ahb1pWPw1C— IDIBELL (@idibell_cat) February 9, 2024 Image for mobile, amp and app Mobile code ????An anticancer drug opens a new path for the treatment of Parkinson’s. ????The results of researchers from @idibell_cat @ICO_oncologia and @IQAC_CSIC open the door to rethinking the use of drugs and their metabolic products in personalized medicine. ???? pic.twitter.com/ahb1pWPw1C— IDIBELL (@idibell_cat) February 9, 2024 AMP Code ????An anticancer drug opens a new path for the treatment of Parkinson’s. ????The results of researchers from @idibell_cat @ICO_oncologia and @IQAC_CSIC open the door to rethinking the use of drugs and their metabolic products in personalized medicine. ???? pic.twitter.com/ahb1pWPw1C— IDIBELL (@idibell_cat) February 9, 2024 APP Code ????An anticancer drug opens a new path for the treatment of Parkinson’s. ????The results of researchers from @idibell_cat @ICO_oncologia and @IQAC_CSIC open the door to rethinking the use of drugs and their metabolic products in personalized medicine. ???? pic.twitter.com/ahb1pWPw1C— IDIBELL (@idibell_cat) February 9, 2024 A new perspective in pharmacology The team of researchers point out that beyond the specific case, this discovery points towards a new conceptual perspective in pharmacology: “the “which considers drug metabolism not as an undesirable process that degrades and eliminates the therapeutic molecule from the body, but rather as one that can have potential advantages from a therapeutic point of view.” The results they have obtained open the door to using this drug in other therapies and discovering new functions on existing medications.
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