Scientists from Canada have discovered a drug that is more effective at battling daytime sleepiness than a cup of espresso. The researchers reviewed previous studies of three anti-fatigue drugs and found that they can be effective in reducing daytime sleepiness. The drugs were tested on people with obstructive sleep apnea who were already using other therapies. Obstructive sleep apnea is a common sleep-related condition where breathing stops and starts throughout the night, putting the body at risk of oxygen deprivation.
The researchers reviewed 14 previous clinical trials with a total of 3,085 participants and compared the effectiveness of three anti-tiredness drugs: solriamfetol, armodafinil-modafinil, and pitolisant. All three drugs were found to be more effective than a placebo at fighting the patients’ tiredness, with solriamfetol having the greatest impact. The participants’ tiredness was measured using self-reported questionnaires and a test called the Maintenance of Wakefulness Test (MWT), which measures alertness during the day.
While armodafinil-modafinil and pitolisant were found to “probably improve” wakefulness after a month of use, the researchers noted that side effects could be an issue for users. For example, solriamfetol has been linked to an increase in blood pressure. The study was published in the journal Annals of Internal Medicine. According to the makers of solriamfetol, the drug can improve wakefulness for up to nine hours, whereas the effects of caffeine typically wear off after four to six hours.
This new discovery has the potential to provide relief for individuals who suffer from daytime sleepiness, especially those with obstructive sleep apnea. However, it is important to consider the potential side effects and consult with a healthcare professional before starting any new medication.