Prof. Dr. Teerawat Hemachutha, Head of Emerging Disease Health Sciences Center Faculty of Medicine Chulalongkorn Hospital Posted on Facebook stating that taking antidepressants for a long time ..risk of death
It is an accident report and the cause is still unclear.
antidepressant drug Depressed, likely to become or almost It has become a common drug for Thai people. Taking antidepressants, anti-anxiety drugs due to insomnia Unable to adapt until it interferes with life, work and homework More than half
in England itself is also It has become the most widely prescribed class of drugs, and in 2018 alone there were 70 million prescriptions, doubling the number of the previous decade. and would be the same all over the world.
The report was published by British researchers funded by the National Institute of Health Research (NI) School for Primary Care Research and by the NI Biomedical Research Center at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol. In the British journal of Psychiatry, September 13, 2022.
by the research team lays the groundwork for new recommendations for the use of antidepressants in 2022, which change from the original This is given in the long term to prevent recurrence. After the symptoms have calmed down It should be at least six months, or up to two years for people who are at risk of recurrent depression.
In England It was found that most of them have been taking the drug continuously for up to 5.5 years, even without clear data on the health effects of giving this family of drugs for a long time.
In vitro studies have reported that antidepressant drugs There is a potential for adverse effects on the metabolic balance of the body and the cardiovascular system.
Human Effects Tracking Data It is unclear because the duration of the follow-up was short and, in addition, depression was linked to obesity, poor nutrition, and obesity. smoking and not exercising
Therefore, careful studies of the effects of these drugs are required in these variables.
for that reason This research team Therefore, data from the UK Biobank data warehouse were used, which contains detailed data on age, gender, weight, BMI, waist and buttock ratio, economic status, behavior, including smoking, drinking, physical activity, underlying disease, health basics, lifestyle, even even deeper Factors that will cause disease All cardio metabolic, collected about 500,000 people.
Of the 500,000 subjects recruited between 2006 and 2010, 222,121 subjects aged 40 to 69 years were recruited, all of whom had at least 12 months of pre-analysis data and had not received antipsychotics. lithium or mania sedative or is already a cardio-metabolic disease and is being treated with medication
after adjusting for variables or other factors that will result in cardiovascular disease Cardiovascular disease CVD, coronary heart disease CHD, and stroke (CV) and all-cause mortality.
It was found that the use of this group These are most commonly mirtazapine, venlafaxine, duloxetine, and trazodone, but selective serotonin reuptake inhibitors (SSRIs) are also effective.
This increases the risk of CHD CVD and approximately doubles the risk of death from CVD.
The risk of CV stroke increased and the risk of death from all causes doubled.
But surprisingly, these drugs reduced the risk of high blood pressure by 23% and the risk of diabetes by 32%.
The researchers could not explain the increased risk of cardiovascular disease. until a marked increase in the risk of death, despite the seemingly beneficial effect on reducing the risk of hypertension and diabetes
However, the data obtained in this study making it necessary to be more careful Especially in the case of long-term use of drugs that There may be random risks that can cause harm. It was previously thought to be harm-free and required communication between the physician and patient to weigh the benefits and side effects of the medication.
and in case of necessity Cardiovascular effects should also be monitored periodically.
Limitations of this study It is unable to clearly explain the cause and effect of drug use.
People who are prone to depression may already be predisposed to these kinds of things.
To establish a cause-and-effect link, one may need evidence based on the nine Bradford Hill criteria: strength, consistency, specificity, temporality, biological gradient, plausibility, coherence experiment analogy. The connection is tighter. from the epidemiological data obtained
in short
This information remains important for everyone to be aware of the use of medication and the need for other aids. to alleviate and cure before taking medication
and when using the drug, avoid taking multiple concomitant drugs whether in the same group or in different groups
And the duration of use should be as necessary so that the body is not the battlefield of the drug eventually. meet someone who is suffering Help each other to be generous to spread. Then we will all be happy.