2023-07-05 11:41:43
Dolly is preserved dissected – WIKIPEDIA
MADRID, 5 Jul. (EUROPA PRESS) –
This July 5 marks the 27th anniversary of the birth of Dolly the sheep, the first mammal cloned from an adult cell. His birth, in 1996, was not announced until seven months later.
Its creators were scientists from the Roslin Institute in Edinburgh (Scotland), Ian Wilmut and Keith Campbell. Dolly was actually a sheep resulting from a nuclear combination from a differentiated donor cell to an unfertilized and anucleated egg (without a nucleus).
The cell Dolly came from was an already differentiated or specialized cell.from a specific tissue, the mammary gland, of an adult animal (a six-year-old Finn Dorset sheep), which was a novelty.
Until then it was believed that clones could only be obtained from an embryonic cell, that is, not specialized. Five months later Dolly was born, which was the only lamb resulting from 277 fusions of enucleated ova with mammary cell nuclei.
Dolly always lived at the Roslin Institute. She there she was crossed with a Welsh Mountain male to produce six pups in total. In the fall of 2001, at the age of five, Dolly developed arthritis and began to walk painfully, successfully treated with anti-inflammatory pills.
On February 14, 2003, Dolly was euthanized due to progressive lung disease. Her species has a life expectancy of about 11 to 12 years. However, Dolly lived for only six and a half years. The autopsy showed that she had a form of lung cancer called Jaagsiekte, which is a disease of sheep caused by the JSRV retrovirus.
The Roslin technicians could not certify that there is a connection between this premature death and being a clone, since other sheep from the same flock suffered and died from the same disease. Such lung diseases are a particular danger in in-house housing, as Dolly’s was for safety reasons.
However, some have speculated that she was a paraplegic, due to her crooked hooves.. There was an aggravating factor to Dolly’s death and that was that she had a genetic age of six, the same age as the sheep from which she was cloned. One basis for this idea was the finding of her short telomeres, which are generally the result of the aging process. However, the Roslin Institute has established that intensive health checks on Dolly did not reveal any abnormalities that might suggest premature aging.
The stuffed remains of Dolly the sheep are on display at the Royal Museum of Scotland, informs Wikipedia.
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