2024-10-14 10:15:00
More than 1.5 million new cases of prostate cancer are diagnosed worldwide every year. As one of the leading causes of death among men in many countries, knowing all the risk factors for prostate cancer has become essential. While the main factors are genetic and may be related to a family history of prostate cancer, many lifestyle factors can significantly increase your chances of developing prostate cancer.
Over the last decade, several studies have been made public whose conclusion is that problems with our intestinal microbiota, known as “gut dysbiosis”, are closely related to prostate cancer. Imbalances in gut bacterial populations, which are often dictated by lifestyle factors and decisions, can contribute to malignancy, disease progression, and a poorer overall prognosis. However, most of the underlying mechanisms linking gut dysbiosis to prostate cancer remain unclear and difficult to study.
To answer these questions, a team led by Chisato Wakamori of Kindai University in Osaka, Japan, used genetically modified mice to simultaneously study intestinal dysbiosis and prostate cancer.
The authors of the new study took stool samples from healthy and tumor-bearing mice, extracted bacterial genetic material, and finally used rRNA sequencing. They then compared this data with that obtained from men who had been tested for suspected prostate cancer.
After careful inspection of the data, these experiments revealed that both humans and mice had marked differences in the composition of their gut microbiome between individuals with and without prostate cancer. Specifically, bacteria from the Odoribacter and Desulfovibrio genera were positively associated with prostate cancer in both species.
Many studies have shown that certain changes in the composition of the intestinal bacterial population are linked to the risk and progression of prostate cancer. (Image: National Institutes of Health (NIH). CC BY-SA)
The study is titled “A cross-species analysis of fecal microbiomes in humans and mice reveals similarities and differences associated with prostate cancer risk.” And it was published in the academic journal The Prostate. (Fountain: NCYT by Amazings)
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