“Covid 19” continues to mutate, “Mo Yong” emphasizes the mutation It has no effect on the use of the latest antiretroviral drugs, almost all of which are strains BA.2.75.
“Mo Yong” Prof. Dr. Yong Phuvorawan Head of the Center of Excellence in Virology Department of Pediatrics Clinic Faculty of Medicine Chulalongkorn University posted via facebook Yong Poovorawan Open up to the case. mutation of “COVID 19”
which has always been studied at the Center for Studying Species with genetic decoding will always see the changes of the species “Omicron” It is a species that has been around since the beginning of the year. But there are descendants as subspecies since the beginning of the epidemic, becoming BA.1 and then changing to BA.2 since June. BA.5 replaced
where BA.4 could not be built up and in these 2 months it was replaced by BA.2.75 which is now a species BA.2.75 almost all, and further if there is an outbreak Western foreign species, BQ.1 and BQ.1.1, will continue to replace them.
However, changes are made all the time. As for the system immunity in preventing infection It is well known that Once infected or vaccinated There is still a chance of being infected again. But the changes that occur will change only the outer skin. The structure of the virus remains the same. Eliminating the virus to reduce the severity of the disease, especially the T cell system, still works well.
developed vaccine will not catch up with changes in the outer surface area Or the species that has changed little by little, the 2-strain vaccine is not much superior to the original vaccine. And when there is another genetic change, it probably won’t be much different. However, when we humans know andMost of the population has immunity. The severity of the disease will decrease. together with better treatment Everything will have a better trend. The species will change forever. little by little like the flu
virus mutation It has no effect on the drug used for treatment.
virus “COVID 19” There have been mutations everyone knows A mutation alters the genetics of the spiky parts. resulting in decreased effectiveness of vaccines used for prevention and antibody drugs including monoclonal antibodies decrease in efficiency
As for the drugs used for treatment, whether remdicevir and molnupiravir Affects viral replication by inhibiting RNA dependence RNA polymerase. paxlovid Block protease enzymes, not in viral mutagenesis
so Current virus mutations therefore have no effect on the efficacy of antiretroviral therapy. in such treatment antiviral drug Therefore, it still has the same treatment efficacy even if the virus mutates.
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