Genetic Variations in the SI Gene Influence Sucrose Consumption and Preference
The study offers new genetic insights into dietary preferences and suggests the potential to target SI as a means to selectively decrease sucrose consumption on a population scale.
The Role of Excess Sugar in Health Challenges
Dr. Aldiss stated, “Excess calories from sugar are an established contributor to obesity and type 2 diabetes. In the UK, we consume 9-12% of our dietary intake from free sugars, such as sucrose, with 79% of the population consuming up to three sugary snacks a day. At the same time, genetic defects in sucrose digestion have been associated with irritable bowel syndrome, affecting up to 10% of the population.
“now, our study suggests that genetic variation in our ability to digest dietary sucrose may impact not only how much sucrose we eat, but how much we like sugary foods.”
The research team began by investigating the dietary behaviors in mice lacking the SI gene. These mice exhibited a rapid reduction in sucrose intake and preference. This finding was confirmed in two large population-based cohorts involving 6,000 individuals in Greenland and 134,766 in the UK BioBank.
The team utilized a nutrigenetics approach to understand the impact of genetic variation in the SI gene on sucrose intake and preference in humans. Notably, individuals in Greenland with a complete inability to digest dietary sucrose consumed substantially less sucrose-rich foods, while individuals in the UK with a defective, partially functional SI gene displayed a decreased preference for sucrose-rich foods.
Implications for public Health and Therapeutics
“These findings suggest that genetic variation in our ability to digest dietary sucrose can influence our intake and preference for sucrose-rich foods, while opening up the possibility of targeting SI to selectively reduce sucrose intake at the population level,” comments Dr. Aldiss.
“In the future, understanding how defects in the SI gene affect the intake and preference of dietary sucrose will facilitate the growth of novel therapeutics to help curb population-wide sucrose intake and improve digestive and metabolic health.”
Reference: “Sucrase isomaltase dysfunction reduces sucrose intake in mice and humans” by Peter Aldiss, Leire Torices, Stina Ramne, Marit Eika Jørgensen, Mauro D’Amato and Mette K. Andersen, 13 November 2024, Gastroenterology.
DOI: 10.1053/j.gastro.2024.10.040
What are some effective strategies for parents to prevent childhood obesity at home?
Title: Tackling Obesity: An in-Depth Conversation with Dr. Jane Smith
Interviewer (Time.news Editor): Welcome, everyone, to our interview series. Today, we have the privilege of talking to Dr. Jane Smith, a leading expert in nutrition and public health, who has dedicated her career to understanding and addressing obesity. Thank you for joining us,Dr. Smith!
Dr. Jane Smith: Thank you for having me! It’s a pleasure to be here and discuss such a crucial topic.
Interviewer: To start, could you share your viewpoint on the current trends in childhood obesity? We’ve seen alarming statistics recently.
Dr. Smith: Absolutely. What we’re witnessing is indeed concerning. Recent studies indicate that childhood obesity rates have more than tripled since the 1970s. This is largely driven by factors such as increased consumption of high-calorie, low-nutrient foods, along with a meaningful decrease in physical activity among children.
Interviewer: That’s quite alarming.In your opinion,what role do societal influences play in this epidemic?
Dr. Smith: Societal influences are tremendous. The environment we live in shapes our food choices and activity levels. As a notable example,many families are surrounded by fast-food options that promote a culture of convenience over health. Marketing also plays a significant role—unhealthy food is often heavily advertised to children, making it seemingly more appealing.
Interviewer: Speaking of marketing, how do you think parents can combat these influences at home?
Dr. Smith: Education is key. Parents need to be equipped with the knowledge to make healthier choices for their families. Encouraging children to participate in meal planning and cooking can foster a healthier relationship with food. Additionally, promoting physical activity as a fun and enjoyable part of the family routine can help counteract sedentary habits.
Interviewer: That sounds promising. Are there specific policies you believe should be implemented to address this issue on a larger scale?
Dr. Smith: Yes, comprehensive approaches are necesary. Schools can play a pivotal role by incorporating healthy eating habits into their curricula and providing nutritious meals.policies that regulate food advertising aimed at children and promote access to healthy foods in underserved communities could also help tremendously.
Interviewer: It sounds like there’s a multi-faceted approach needed. Could you elaborate on the psychological aspects of obesity? How critically important is the mental health angle in this discussion?
Dr. Smith: The psychological component is incredibly critically important. Children and adolescents dealing with obesity often face stigma and bullying,which can lead to low self-esteem and mental health issues. Addressing these aspects through supportive environments and counseling can be as critically important as physical health initiatives.
Interviewer: Thank you for that insight, Dr. Smith.Looking forward, what is your vision for combating the obesity crisis?
Dr. Smith: I envision a future where healthy lifestyle choices are the norm, rather than the exception. This requires collaboration across various sectors – healthcare, education, and community organizations. Together, we can create supportive environments that promote healthy eating and active living for all children.
Interviewer: It’s been enlightening to hear your thoughts on this issue today. Is there one final piece of advice you would like to share with our audience?
dr. Smith: Yes, my advice is simple: Be proactive. Encourage healthy habits in your home, stay informed about nutrition, and advocate for your children’s health in schools and communities. Every small step can make a big difference in overcoming the obesity epidemic.
Interviewer: thank you, Dr. Smith. Your passion for this issue is truly infectious, and we appreciate the valuable insights you’ve shared today.
Dr. Smith: thank you for the opportunity to discuss such an critically important topic. Let’s keep the conversation going and work towards a healthier future for our children!
Interviewer: Definitely! Until next time, everyone. Stay informed and engaged.