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Heart failure patients who are not vaccinated against SARS-CoV-2 are three times more likely to die if infected with the virus compared to vaccinated heart failure patients, according to new research from Mount Sinai Heart.
The study, published in the “Journal of Cardiac Failure”, is the first to analyze the status of vaccination against Covid-16 and the results in patients with this cardiovascular disease and shows how drastic the protective effects are in this population of high risk patients.
The research is important as many heart failure patients are hesitant to receive the Covid-19 vaccine for fear of myocarditis, or inflammation of the heart muscle. The results of this work can help you better understand the benefits of being fully vaccinated and boosted against Covid-19, and the protection it offers.
“I started this study because our patients with heart failure they often express their fear of receiving the Covid-19 vaccine after hearing reports of vaccine-related myocarditis, which would cause another heart attack.
Until now, it has been difficult to explain to these patients how cardiovascular benefits of vaccination substantially outweigh the risks of complications for them, because we did not have concrete evidence showing substantial risks of not being vaccinated, as few studies have focused on this specific high-risk population and vaccination against Covid-19,” he says. Anurhada Lala, Director of Research at the Icahn School of Medicine at Mount Sinai.
“Having specific data showing that heart failure patients who don’t have their full series of vaccines have a much higher risk of death, intensive care unit (ICU) admission, and overall hospitalization — even after accounting for the factors that could be related to the individual decision to be vaccinated – is useful.”
Mount Sinai researchers conducted a retrospective study to analyze the impact of Covid-19 vaccination status on the population of heart failure patients. They examined the electronic records of 7,094 Mount Sinai Health System patients with a diagnosis of heart failure (not including heart transplant and left ventricular assist device patients) who had office visits, emergency department visits, or hospitalizations. between January 1, 2021 and January 24, 2022.
Of that group, 2,200 (31%) were fully vaccinated with two doses, 1,053 (14.8%) were fully vaccinated and had also received a booster – guidance recommended by the Centers for Disease Control and Prevention at the time ; 645 (9.1%) were partially vaccinated with a single dose, and 3,196 (45%) were unvaccinated. That proportion of unvaccinated in this study is about twice the proportion of unvaccinated adults in the general New York City population.
The researchers compared survival rates and the number of admissions to hospital and intensive care units between the groups, taking into account both all-cause mortality and mortality associated with concurrent and documented SARS-CoV infection. -two.
They found that unvaccinated and partially vaccinated patients were three times more likely to die from a Covid-19-related illness than fully vaccinated patients. vaccinated and reinforced.
The study also shows that unvaccinated and partially vaccinated patients were 15% more likely to be hospitalized if infected with the virus and almost twice as likely to be admitted to the ICU compared to fully vaccinated and boosted patients.
“The results further underscore that heart failure patients should take vaccinations seriously, as they have worse outcomes if infected with Covid-19, and underscore the importance of receiving the full dose of Covid-19 vaccination, especially as our previous work shows that those with heart failure are 2.5 times more likely to die from the virus,” adds Lala.
“I have used these results to help educate reluctant patients and in many cases this has been effective in encouraging them to continue with full vaccination. The hope is that cardiologists will use these results as a tool to help their patients and to improve their chances of survival.
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