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Updated:05/06/2022 16:49h
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A blood test can become a useful tool to discover specific biomarkers of suicide risk. This has been seen by a team of researchers led by the University of California (USA) who have used a novel approach to gene expression and gene expression quantification less sensitive to the effects of RNA degradation (NanoString).
In addition to identifying individuals at increased risk of suicide, the results of the study published in Translational Psychiatry. they can help researchers understand molecular changes in suicide victims.
“These blood biomarkers are an important step towards the development of blood tests to identify patients at imminent risk of ending their lives,” said author Adolfo Sequeira.
After analyzing data from blood and brain samples from suicide victims, the researchers found changes in stress response gene expression, including polyamine metabolism, circadian rhythm, immune dysregulation, and maintenance of telomeres
The team used data from blood samples (RNA) in combination with gene expression data from blood and brain samples from the same subjects.
Subjects without a psychiatric diagnosis (nonsuicidal) and subjects with major depression who died by suicide or natural causes were included in the study.
“To our knowledge, this is the first study looking at blood and brain samples in a well-defined population of people with major depression demonstrating significant differences in gene expression associated with completed suicide.”
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