Endometrial Receptivity Analysis (ERA): Increasing IVF Success率 with Endometrial Readiness Testing

2024-03-28 15:36:53

Examination of the readiness of the endometrium

Stress, the pressure of having to deal with repeated embryo failures is one of the challenges for couples who want to undergo IVF. But with modern technology, such as endometrial readiness testing, it may be an option to increase the chance of conceiving for those with infertility problems.

What is the endometrial readiness test?

Endometrial Receptivity Analysis (ERA) It measures the thickness of the endometrium and examines the genetic code to assess whether the endometrium is ready for embryo implantation or not. Helps doctors determine the appropriate time period for patients to receive progesterone. Before transferring the embryo into the womb Helps increase the chance of embryo implantation. Pregnancy and continuation of pregnancy Because the implantation of the embryo can be successful only when the uterus is ready.

What is the endometrium?

The endometrium is the tissue lining the inside of the uterus. Consists of 2 layers of tissue: stratum basalis is a layer of tissue attached to the smooth muscle layer of the uterus. Does not peel off during menstruation and stratum functionalis which will thicken and peel off during menstruation.

Estrogen and progesterone cause the uterus to thicken. Ready for embryo implantation

What is the readiness of the uterus?

Endometrial Receptivity occurs when the lining of the uterus is thick enough for implantation and nourishment of an embryo. The readiness period or window of readiness (window of receptivity) occurs within a short period of time.

At day 20-24 of a normal menstrual cycle (28 days), the endometrial tissue begins to undergo changes in gene expression. Molecular secretion and structural changes To prepare for the embryo The success of embryo implantation also depends on the stage of the embryo. That is, the embryo must be at the blastocyst stage on day 5 or 6 and have normal chromosomes (euploidy). Abnormal embryos often fail to implant or suffer early miscarriage.

Pregnancy will not occur. In the following cases

• It does not correspond to the period when the uterus is ready for implantation.
• The larvae do not grow.
• The embryo has chromosomal abnormalities.
• The endometrium does not have the proper genetic expression or is not ready for implantation.

Uterine readiness is essential for natural pregnancy and IVF. However, the period of readiness will vary from person to person. It depends on the level of progesterone and the genetic expression of the endometrial tissue.

Why should those undergoing IVF undergo a test for endometrial readiness?

Endometrial readiness testing is suitable for women who have a history of embryos not implanting or who have had multiple unsuccessful IVF cycles. The endometrial readiness test can detect the expression of 236 genetic codes to determine the most suitable time for embryo implantation. Because the right time will increase your chances of getting pregnant. The appropriate period is usually between the 19th and 23rd day of the menstrual cycle. About 80% of women will be ready during this period, while the other 20% will usually be ready before or after this period. This allows you to determine whether the readiness window is open or closed. Before embryo transfer It plays a very important role in IVF.

What are the procedures for testing the readiness of the endometrium?

• Those undergoing the examination must take medicine or injections as ordered by the doctor. To stimulate the creation of endometrial tissue. Your doctor will perform an ultrasound and blood test to monitor your body’s response to the medicine.
• The doctor will take a biopsy to analyze the genetic makeup.
• The doctor will assess whether the endometrial tissue is ready for implantation or not.
• If the uterus is not ready for implantation The doctor will adjust the administration of progesterone. and postponing embryo transfer to the next menstrual cycle to increase the chance of pregnancy

What are the results of the endometrial readiness test?

The results of the endometrial readiness test can be divided into 3 types.

• Receptive result: The endometrium is most prepared for implantation. Patients receiving the treatment receive the appropriate amount of progesterone. Embryo transfer can be done
• Pre-receptive result: Patients receiving treatment received insufficient progesterone. Therefore, the endometrium is not ready for implantation of the embryo. Longer progesterone exposure is required. for at least 12-24 hours before transferring the embryo into the womb
• Post-receptive result: The patient received progesterone too quickly. Another biopsy should be done to confirm the appropriate time to receive hormones.

Sometimes the results may be inconclusive. But it is rarely found.

Advice from doctors at Medpark Hospital

For those who have infertility Trying to conceive can be challenging. A team of doctors who are experts in reproductive medicine at MedPark Hospital ready to give advice The examination and treatment methods are appropriate to the health history of each patient receiving treatment. If interested in receiving counseling, please contact. Infertility treatment center and assisted reproductive technology Medpark IVF Tel. [phone]

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Published: 20 Mar 2024

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